Week beginning 28th July 2025
Part 2 of 2
Research
ME/CFS research
Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera — Mughal et al.
"findings indicate that patient sera not only lowered the overall ability of the muscle to execute work but post peak performance, the tissues experienced weakness and inability to reach the same performance again"
Article |
Thread
Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome — Komaroff and Dantzer
"The central focus of this review is to propose an additional cause of the symptoms, one that can be triggered by the underlying abnormalities and that might be more easily targeted for therapy."
Article |
Thread
More than meets the eye: An exploration of secondary school experiences and support for children and young people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) — Ellen Cookson
"this research amplifies the voices of CYP with lived experience of ME/CFS, illuminating their experiences, strengths, and challenges in navigating secondary school and support within it. While schools were often responsive to physical and cognitive needs associated with ME/CFS, the research highlights that there is more to CYP’s experiences than meets the eye. The invisibility of the condition, delegitimisation, and overlooked [Social, Emotional and Mental Health] needs contributed to feelings of loss, isolation and a lack of support, exacerbating challenges for CYP."
Thesis |
Thread
Beyond fatigue: an intersectional analysis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and social identities — Sirotiak and Thomas
Article |
Thread
Long Covid research
Peripheral immune progression to long COVID is associated with mitochondrial gene transcription: A meta-analysis — Maison et al.
"we observed mitochondrial dysfunction in mononuclear cells and granulocytes in people experiencing LC. Whereas the direct cause of immune cellular/metabolic function is not known, our data suggest that SARS-CoV-2 may have a long-term impact on a variety of different cell types, either due to direct or indirect effects of viral infection and potential viral persistence."
Article |
Thread
Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort — Candace H. Feldman et al.
"Among 3787 participants, 418 (11%) developed long COVID." "Participants with social risk factors at the time of SARS-CoV-2 infection had greater risk for subsequent long COVID than those without."
Article |
Thread
Blood-Brain barrier disruption in long COVID and cognitive correlates: A cross-sectional MRI study — Rubin et al.
"We identified PEM as a self-reported symptom associated with increased BBB permeability in the LC group." "Reporting symptoms of dizziness […] was associated with decreased BBB permeability. Dizziness is thought of as a symptom of orthostatic intolerance; we would expect its presence to be associated with a decrease in cerebral blood flow and, thus, an increase in BBB permeability."
Article |
Thread
Screening for postural orthostatic tachycardia syndrome using 24-hour electrocardiogram recording in patients with long coronavirus disease — David Hupin et al.
"A triple analysis of 24-hour ECG recordings in LC POTS+ revealed an increased number of HR spikes, prolonged increase in HR after awakening, and significantly reduced HRV. This novel analysis may be introduced in addition to the clinic for accelerating screening and therapy monitoring in LC-related cardiovascular autonomic dysfunction."
Article |
Thread
Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates — Kristin A. Sauter et al.
"The development of specific aspects of PASC in lean animals, including those associated with metabolic dysfunction such as a decreased [adiponectin/leptin ratio], and increased nighttime activity, suggests that, while preexisting obesity can increase the risk for some components of PASC such as long-term lung pathology, other aspects of PASC can develop in the absence of pre-infection obesity."
Article |
Thread
Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide — Lael M. Yonker et al.
"we report results from a phase 2a randomized, double-blind, placebo-controlled clinical trial testing the zonulin antagonist larazotide in 12 children with MISC with a median age of 5.7 years." "Children treated with larazotide displayed faster resolution of gastrointestinal symptoms, faster clearance of spike antigen, and a faster return to usual activities."
Article |
Thread
Functional Connectivity Changes in Long-Covid Patients with and without Cognitive Impairment — Leitner et al.
"Patients with cognitive deficits showed higher functional connectivity (FC) between the default mode network (DMN) and parts of the posterior supramarginal gyrus, angular gyrus and posterior-occipital part of the middle temporal gyrus, compared to those cognitively unimpaired."
Article |
Thread
Sex differences in inflammation and markers of gut integrity in long COVID — Durieux et al.
Article |
Thread
Functional Autoantibodies Targeting G-Protein-Coupled Receptors and Their Clinical Phenotype in Patients with Long-COVID — Hofmann et al.
"Most patients with LC showed a seropositivity of β 2-fAAb (92.8%), M2-fAAb (87.1%), AT1-fAAb (85.6%), and MAS-fAAb (85.6%). Seropositivities of α1-fAAb (16.0%), Nociceptin-fAAb (14.4%), and ET-A-fAAb (2.6%) were a less common feature in the study cohort. There was no gender effect across the different GPCR-fAAbs."
Article |
Thread
Symptomatic Trends and Time to Recovery for Long COVID Patients Infected During the Omicron Phase — Akiyama et al.
"women with a follow-up period longer than 180 days were significantly more likely to report fatigue, insomnia, memory disturbance, and paresthesia, while men in the same group reported a higher frequency of headaches." "no obvious differences in blood test data were observed even in cases with longer follow-up periods than 180 days. However, both male and female patients with a long follow-up period had higher LDL-C levels."
Article |
Thread
Perioperative and anesthetic considerations for post-acute sequelae of COVID (PASC)/long COVID— Yogendra et al.
"A thorough preoperative evaluation should concentrate on assessing cardiovascular, respiratory, neurological, and endocrine/metabolic changes" "Intraoperatively, the selection of anesthetics must consider individual patient conditions, alongside tailored strategies for fluid and pain management." "Postoperative care involves intensive monitoring in the post-anesthesia care unit (PACU) for any signs of symptom exacerbation, implementation of multimodal pain management, and meticulous discharge planning"
Article |
Thread
Chronic inflammation in Long COVID relationship to autoimmune diseases — Chen et al.
"the impact of the Long COVID on the respiratory and immune systems is profound, and there are substantial gaps in the global understanding of the exact specific pathophysiology of the Long COVID syndrome."
Article |
Thread
Long COVID and the Military: A Current Research Landscape, Knowledge Gaps, and Future Directions — Pollett et al.
"Many considerations in this review article may also apply to post-acute sequelae from other infectious diseases, which pose risks to military health and readiness, including future respiratory virus pandemics."
Article |
Thread
Pre-COVID health-related quality of life predicts symptoms and outcomes for patients with long COVID — Lapin et al.
"poor concentration/brain fog and memory deficits were among the highest associations with worse pre-COVID mental health, whereas fatigue, exertional intolerance, and joint pain/body aches exhibited among the highest associations with pre-COVID physical health."
Article |
Thread
Chronic health consequences of the COVID-19 pandemic on school workers: a cross-sectional post-pandemic analysis — Allison W Watts et al.
"About 1 year after the first Omicron wave in BC, a significant proportion (about one-third) of school staff reported chronic symptoms." "the high prevalence of new-o chronic symptoms in the latter stages of the pandemic is concerning, especially considering that most infections occurred post-vaccination."
Article |
Thread
Systematic review of post-COVID condition in Nordic population-based registry studies — Himmels et al.
"Nordic registry studies report an incidence of PCC in the general population to be less than 2%. This corresponds well with the finding that most COVID-19 patients return to work three months post-infection, with less than 2% of all COVID-19 patients still on sick leave after six months."
Article |
Thread
Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge — von Werder et al.
"we have provided first evidence that while breathing control is mostly intact, processes in the brain for symptom perception are erroneous in patients with post-COVID syndrome. We have suggested different computational mechanisms that could underlie this erroneous processing in a Bayesian brain framework."
Article |
Thread
...........
S4ME social media:
Forum,
Mastodon,
Bluesky