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Scientists find important biomarkers in post-covid
2025-08-11
Researchers at Uppsala University have made important progress in understanding post-COVID and ME (myalgic encephalomyelitis). Jonas Bergquist and his research group have identified biomarkers for inflammation in both cerebrospinal fluid and blood in patients with long-term problems after infections.
During Almedalen Week, Jonas Bergquist presented new research results at the seminar "The post-infectious elephant in the room". The Swedish Covid Association and the National Association for ME were present, among others.
Both ME and post-covid are multifactorial diseases and the patient group is growing. Jonas Bergquist's research focuses on understanding why some patients develop long-term symptoms after recovering from an infection.
Inflammation markers in cerebrospinal fluid and blood
The research team has made two important discoveries. First, they found neuroinflammation markers in cerebrospinal fluid – the fluid surrounding the brain – in patients with ME. Then, the team, together with collaborators, published an article on post-COVID patients. In that patient group, inflammation markers were also found, although this time also in the blood. The article was published in May 2025 and gives new hope for post-COVID patients.
The study they talk about is here:
Long-term symptoms such as pain, fatigue, and cognitive impairments are commonly observed in individuals affected by coronavirus disease 2019 (COVID-19). Metabolites of the kynurenine pathway have been proposed to account for cognitive impairment in COVID-19 patients. Here, cerebrospinal fluid...
pubmed.ncbi.nlm.nih.gov