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News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments (2019) Comhaire et al.

Discussion in 'BioMedical ME/CFS Research' started by Badpack, Nov 1, 2019.

  1. Badpack

    Badpack Established Member (Voting Rights)

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  2. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    Thanks for posting. I know many are negative on Comhaire’s work, but at least he is investigating some potential treatment options.
     
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  3. Cheshire

    Cheshire Moderator Staff Member

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    Abstract
     
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  4. Badpack

    Badpack Established Member (Voting Rights)

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    @Jaybee00 oh thanks for letting me know haha. Didnt hear his name before. Was just browsing through some studies and found it an interesting read. Because my main symptom right now is frontal brain pain and brain fog to the grade that i forget my own name :/ thats why the Meldonium treatment seemed interesting to me with the brain scans. Also didnt find anyone here in the forum who ever tried it before.
     
    Last edited: Nov 1, 2019
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  5. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    @Badpack

    Comhaire posts here under the name “ME/CFS”. You could @ him if you have questions.

    Meldonium is available online... not so expensive.
     
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  6. dreampop

    dreampop Senior Member (Voting Rights)

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    Famously taken by Maria Sharapova for a decade, according to her. Ended in a 1-year ban.
     
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  7. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    I don't quite understand the rationale of using these drugs.

    Meldonium inhibits fatty acid oxidation (through inhibiting carnitine acetyltransferase, Carnitine Transporter 2 and γ‐butyrobetaine hydroxylase).
    There is some evidence that fatty acid oxidation is already (compared to controls) relatively inhibited in ME & CFS patients.
    https://pubs.rsc.org/en/content/articlelanding/2017/mb/c6mb00600k/
    https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2796.2010.02341.x (suggests that there is already higher peroxisomal utilization of fatty acids, suggesting lower carnitine palmitoyltransferase-I activity)

    The therapeutic rationale is to encourage glycolysis but that doesn't seem to be a problem in patients (Fluge & Mela, Hanson etc).

    See also (mechanisms of action) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188923/ (Misuse of the metabolic modulator meldonium in sports)
     
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  8. Trish

    Trish Moderator Staff Member

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    We have previous threads on Comhaire's research using his mix of sodium dichloroacetate and some nutritional supplements in a mixture he was trying to patent.

    If you read the discussion on those threads, you will see that forum members were unimpressed by his overblown claims of efficicacy based on small short term open label trials with subjective outcome measures.

    He tried to do some fancy predictive mathematical models for which patients would respond but seemed not to understand that you have to make the model on one set of data and test if it works on a different set.

    https://www.s4me.info/threads/a-nov...ment-of-me-cfs-frank-comhaire-sept-2017.1036/

    https://www.s4me.info/threads/treat...th-sodium-dichloroacetate-comhaire-2018.2885/
     
  9. Badpack

    Badpack Established Member (Voting Rights)

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    Mhh ok sounds pretty dubious after looking into your links. Did some ppl from the forum really try dichloracetat or Meldonium ?
     
  10. rvallee

    rvallee Senior Member (Voting Rights)

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    I, um, yeah, well, there are definitely more than 5 grains of sand in a handful and a blue whale is definitely at least more than 20kg.

    Not much to interpret. Open label with self-reported outcomes. The fatigue questionnaire doesn't look particularly relevant. Doesn't look bad so much as not particularly useful.
     
  11. Trish

    Trish Moderator Staff Member

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    I've just read through the paper. What a muddle of speculation, bits of rather vague biology, repetition, claims of effectiveness based on open label studies with subjective outcomes,.. oh and rats too.
     
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  12. Kalliope

    Kalliope Senior Member (Voting Rights)

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