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Neurotoxicity in Gulf War Illness and the Potential Role of Glutamate, 2020, Joyce and Holton

Discussion in ''Conditions related to ME/CFS' news and research' started by Andy, Jun 26, 2020.

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  1. Andy

    Andy Committee Member

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    Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0161813X20300954
    Not available via Sci hub at time of posting.
     
    Andy, Jun 26, 2020
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  2. mariovitali

    mariovitali Senior Member (Voting Rights)

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    This is very interesting. For the people that have been following the research using Machine Learning methods, there was a hypothesis -since 2015- that Gulf War Illness Syndrome, Post Finasteride Syndrome , Post-treatment Lyme disease syndrome and ME/CFS have common mechanisms.

    Here is a recent tweet on Pesticides (more specifically Organophosphates) one of the most important aspects is that we have people getting ME from other means apart viruses. Observe the role of Glutamate on Organophosphate (OP) poisoning here as well:


    https://twitter.com/user/status/1275748376831832066



    Screen Shot 2020-06-24 at 14.09.39.png


    Screen Shot 2020-06-24 at 14.04.44.png
     
    Last edited: Jun 26, 2020
    mariovitali, Jun 26, 2020
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  3. Midnattsol

    Midnattsol Moderator Staff Member

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    But glutamate is not very specific. It can also be affected by lifestyle factors like diet and activity levels. Excitotoxicity is also linked to suicide ideation, psychosis, major depression, autism, I guess cognitive impairment (can't remember) and the whole glutamine/glutamate relationship and how it's important for metabolism.

    I believe it's important, you don't want dysregulation of glutamate, but I'd be more surprised if they hadn't found anything.
     
    Midnattsol, Jun 26, 2020
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  4. mariovitali

    mariovitali Senior Member (Voting Rights)

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    This is true. I am very excited with the DecodeME project because the number of data will help us identify subtypes that potentially lead to the same result. What i am trying to say is that we may have not only issues with Glutamate but also with Glutathione production (an example). Another subtype may have issues with Cysteine catabolism. These with a minor issue in mitochondrial functioning could make the perfect storm. As you know i am not a medical professional, these are just speculations.
     
    mariovitali, Jun 26, 2020
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  5. Midnattsol

    Midnattsol Moderator Staff Member

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    I agree, DecodeME is going to be fascinating!

    Glutamate, glutathione, cysteine and mitochondria is very interesting as well, especially for a nutritionist/cell biologist :D
     
    Midnattsol, Jun 26, 2020
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  6. spinoza577

    spinoza577 Senior Member (Voting Rights)

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    :rofl::rofl::rofl:
     
    spinoza577, Jun 26, 2020
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  7. Midnattsol

    Midnattsol Moderator Staff Member

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    The worst is I did not think about the obvious pun when I wrote it :facepalm::laugh:
     
    Midnattsol, Jun 27, 2020
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  8. mariovitali

    mariovitali Senior Member (Voting Rights)

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    mariovitali, Jul 12, 2020
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  9. mariovitali

    mariovitali Senior Member (Voting Rights)

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    I realised that pyridostigmine bromide - PB (aka MESTINON) is hypothesised as one of the causes of Gulf War Illness :


     
    mariovitali, Jul 12, 2020
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