Neuroinflammation disorders exacerbated by environmental stressors, 2019, O'Callaghan & Miller

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https://www.sciencedirect.com/science/article/abs/pii/S0026049519301489

Metabolism
Volume 100, Supplement, November 2019, 153951

Neuroinflammation disorders exacerbated by environmental stressors
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James P.O'Callaghan
Diane B.Miller†
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America
Received 29 June 2019, Revised 16 July 2019, Accepted 18 July 2019, Available online 11 October 2019.


https://doi.org/10.1016/j.metabol.2019.153951
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Abstract
Neuroinflammation is a condition characterized by the elaboration of proinflammatory mediators within the central nervous system. Neuroinflammation has emerged as a dominant theme in contemporary neuroscience due to its association with neurodegenerative disease states such as Alzheimer's disease, Parkinson's disease and Huntington's disease. While neuroinflammation often is associated with damage to the CNS, it also can occur in the absence of neurodegeneration, e.g., in association with systemic infection. The “acute phase” inflammatory response to tissue injury or infections instigates neuroinflammation-driven “sickness behavior,” i.e. a constellation of symptoms characterized by loss of appetite, fever, muscle pain, fatigue and cognitive problems. Typically, sickness behavior accompanies an inflammatory response that resolves quickly and serves to restore the body to homeostasis. However, recurring and sometimes chronic sickness behavior disorders can occur in the absence of an underlying cause or attendant neuropathology. Here, we review myalgic enchepalomyelitis/chronic fatigue syndrome (ME/CFS), Gulf War Illness (GWI), and chemobrain as examples of such disorders and propose that they can be exacerbated and perhaps initiated by a variety of environmental stressors. Diverse environmental stressors may disrupt the hypothalamic pituitary adrenal (HPA) axis and contribute to the degree and duration of a variety of neuroinflammation-driven diseases.

Keywords
ME/CFS
GWI
Chemobrain “sickness behavior” stressors
Neuroimmune
Neuroinflammation

†
Deceased October 6, 2017.
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Decent article. I feel like investigating the cause for "sickness behavior" probably wont lead anywhere though.. I highly doubt this theory that were genetically stuck in some dauer larvae state, but Ive lately thought what Jonathan thought about ME potentially being a signalling disease, due to some kind of epigenetic shift, made some sense.
 
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I thought the author information was interesting, detailing the CDC. I wonder what led to this paper being written....... Virtually nothing comes out of the CDC for ME despite significant funding.
Neuroinflammation disorders exacerbated by environmental stressors
James P. O’Callaghan*, Diane B. Millery
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America
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