Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Chronic Fatigue: Three Distinct Entities Requiring Complete Different Approaches (2019) Twisk

JohnTheJack

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Summary
ME, CFS, and CF are three very distinct clinical entities. Interventions justified by (bio)psychosocial models appear to be unsuccessful and potentially noxious. To develop effective treatments, it is crucial to make a clear distinction between ME, CFS, and CF and to leave the (bio)psychosocial explanations and therapies behind us.

https://link.springer.com/article/10.1007/s11926-019-0823-z
 
A review in Current Rheumatology Reports [1] concludes: “Substantial overlap of self-reported psychological, physical, and functional impairments exist between chronic fatigue (CF) and myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS)” and highlights “a need for longitudinal studies integrating biopsychosocial approaches to inform early management and targeted rehabilitation strategies.”
[My bold]
My highlighted text is a huge clue why the review's conclusion is so flawed.
 
Letter to the Editor

ME (Ramsay) and ME-International Case Criteria (ME-ICC): two distinct clinical entities

F. Twisk
The review of the differences and similarities in the different case definitions for myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) by Lim and Son [1] deserves appreciation. Based on their analysis the authors acknowledge the “distinct view of ME and CFS” [2] and recognize four categories of case definitions: ME, ME/CFS, CFS [3] and Systemic Exertion Intolerance Disorder (SEID) [4].

Indeed these labels reflect very different case definitions [5]. According to Lim and Son [1] the first category comprises two ‘ME’ case definitions: ME (Ramsay) [6] and ME according to the International Case Criteria (ME-ICC) [7]. However as can be deduced from Table 2 [1], ME [6] and ME-ICC [7] are two distinct clinical entities [8].
full letter
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02617-0
 
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