Myalgia, amitriptyline and alternatives

@Allele What dose of PEA do you use? And do you split dose? I've never heard of this stuff before, so I'm intrigued and may research it when I have the energy. A quick check on Google and Amazon suggests it may be too expensive for me, whatever its benefits.

Edit : I found a version of this stuff for animals, advertised under the name :

"Pharmox Dog and Cat PEA"

The name wasn't appealing for some reason. :D
 
Last edited:
Arnie Pye said:


"Pharmox Dog and Cat PEA"

The name wasn't appealing for some reason. :D
Click to expand...

:rofl: Arnie Pie you're on a roll today!

I basically take 1 350mg capsule at night, with a daytime dose when I remember (I often forget my daytime doses of everything, even with alerts, am so forgetty.)

I have no idea if this works in combo with the other things I'm taking, but the shift was remarkable soon after I started taking it.
Since it has some action via the cannabinoid receptors, it might be working so well for me bc I also use the raw juice of cannabis (non-psychoactive) which greatly reduces inflammation for me. But if there is or is not a synergistic effect I couldn't say as I am not a chemist or pharmacologist :nerd:

[QUOTE]
[B]Palmitoylethanolamide[/B] ([B]PEA[/B]) is an endogenous [URL='https://en.wikipedia.org/wiki/Fatty_acid_amide']fatty acid amide[/URL], belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the [URL='https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_alpha']peroxisome proliferator-activated receptor alpha[/URL] (PPAR-α).[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-O'Sullivan-2'][2][/URL][URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-LoVerme2005-3'][3][/URL] PEA also has affinity to cannabinoid-like G-coupled receptors [URL='https://en.wikipedia.org/wiki/GPR55']GPR55[/URL] and [URL='https://en.wikipedia.org/wiki/GPR119']GPR119[/URL].[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-Godlewski2009-4'][4][/URL] PEA cannot strictly be considered a classic [URL='https://en.wikipedia.org/wiki/Endocannabinoid_system']endocannabinoid[/URL] because it lacks affinity for the cannabinoid receptors [URL='https://en.wikipedia.org/wiki/CB1_receptor']CB1[/URL] and [URL='https://en.wikipedia.org/wiki/CB2_receptor']CB2[/URL].[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-O-5'][5][/URL] However, the presence of PEA (and other structurally related [URL='https://en.wikipedia.org/wiki/N-acylethanolamine']N-acylethanolamines[/URL]) has been known to enhance anandamide activity by an "[URL='https://en.wikipedia.org/wiki/Entourage_effect']entourage effect[/URL]".[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-6'][6][/URL][URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-7'][7][/URL]

Several papers have demonstrated that an imbalance of the endocannabinoid system (ECS) and alterations in the levels of PEA occur in acute and chronic inflammation.[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-8'][8][/URL] For instance during β-amyloid-induced neuroinflammation the deregulation of cannabinoid receptors and its endogenous ligands accompanies the development and progression of disease.[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-D'Agostino_G-9'][9][/URL]

PEA has been shown to have [URL='https://en.wikipedia.org/wiki/Inflammation']anti-inflammatory[/URL],[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-LoVerme2005-3'][3][/URL] [URL='https://en.wikipedia.org/wiki/Anti-nociceptive']anti-nociceptive[/URL],[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-Calignano2001-10'][10][/URL] neuroprotective,[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-Koch2011-11'][11][/URL] and [URL='https://en.wikipedia.org/wiki/Anticonvulsant']anticonvulsant[/URL] properties.[URL='https://en.wikipedia.org/wiki/Palmitoylethanolamide#cite_note-Lambert2001-12'][12][/URL]
[/QUOTE]
 
You must log in or register to reply here.
Back
Top Bottom