Ive started to get all over muscle pain back again and bad headaches. This is frustrating as I used to get this a lot (even when relatively mild) but it had more or less gone. It is bad enough to disturb my sleep. In the past I used to take amitriptyline to help regulate my body clock. If you haven’t heard of amitriptyline, it was developed as an antidepressant, though it’s actually not very good at that. But the sleepiness it causes is a useful alternative to sleeping pills and it can relieve pain. I think it used to help me generally at a children’s dose, but I developed a side effect of needing to wee a lot in the night, defeating the point so I stopped taking it years ago. I was intending to ask about going back on it and trying again, for both pain and sleep, but I checked on drugs.com and my current drug combo (ivabradine, florinef, bisoprolol) has major interactions with amitriptyline and similar. What do you do for all over ME pain? Paracetamol and ibuprofen don’t seem to touch it. I don’t really want to get into potentially addictive opioid painkillers. Suggestions which are realistic on the NHS please!