My e-book “Tracing Chronic Fatigue Syndrome to mtDNA” will be free Wednesday and Thursday on Amazon

Mithriel said:
Coxsackie B. which I had at the start of my ME and which was implicated in the epidemics is a close relative of polio and is an RNA virus so mitochondrial involvement is very likely.
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Thanks @Mithriel

I agree. In the 2014 study "Impairment of Myocardial Mitochondria in Viral Myocardial Disease and Its Reflective Window in Peripheral Cells", the researchers methods included: "The mouse model of viral myocarditis (VMC) was established by Coxsackie virus B3 infection and myocardial tissues and skeletal muscle were collected. Mitochondrial DNA (mtDNA) deletion rate was quantitatively determined using polymerase chain reaction."

They concluded: "Mitochondrial damage is an important pathophysiological mechanism leading to myocardial injury and cardiac dysfunction. The mitochondrial damage in the skeletal muscle and lymphocytes reflect a “window” of myocardial mitochondrial damage."
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116239
......

"The present study was designed to provide more evidence for the roles of the mitochondrial damage in the pathogenesis of viral myocardial disease. Moreover, given the limitations of clinical application of myocardial biopsy, we also studied the mitochondrial damages in skeletal muscle, peripheral blood samples, and myocardium and analyzed their correlations in order to obtain a “window” in peripheral cells which reflects mitochondrial damage in myocardium."
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116239
 
BeautifulDay said:
Nova Southern University is recruiting for an ME/CFS Gene Study:
https://www.nova.edu/nim/research/mecfs-genes.html
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They have my data already. My physical location and my ME severity prevent me from participating in most research so contributing my dna data is one of the few things I can do. I would like to encourage everybody here with dna data to consider contributing their data, too, obviously after thinking through any privacy concerns that may apply to your specific situation.
BeautifulDay said:
Overshooting the metabolism can cause other issues. Take ALS for example.
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You (almost) made me feel grateful that I ended up with hypo- rather than hyper-metabolism. My father-in-law died of ALS and if there's one disease I wouldn't want to trade for my ME it's that one. It's awfuller than awful (excuse the grammar).

Thank you for all your detailed and informative answers @BeautifulDay. I appreciate the time and energy that must be taking you.
 
Ravn said:
I would like to encourage everybody here with dna data to consider contributing their data, too
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I wrote to them and filled everything in etc. etc. But my DNA data file is too big for .csv, .txt., xlsx or .zip and they only accept 23andme and ancestry. They didn't reply when I asked about WGS data (which will be by other providers or geneticists).
 
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