Monitoring Carotid Blood Flow Using In-Ear Wearable Device During Tilt-Table Testing, 2023, Hemantkumar Tripathi MD et al

[Jonathan Edwards]

the great thing about the POTS researchers, and the patients, and this company, and hopefully a few competitors, is they will chug along anyway and we can find out if your view was right.

But will the chugging ever show anything?
The Y axis is number of symptoms - which seems a crazy thing to measure. One bad symptom is enough. Maybe the chart misses the real relation. But this isn't supporting evidence.

 

[Simon M]

That graph is pretty overwhelming evidence that reduced blood flow is NOT the cause of symptoms. A primary main cause does not give a correlation line like that with an R of 0.4. It gives an R of 0.9+.

The Y axis is number of symptoms - which seems a crazy thing to measure. One bad symptom is enough. Maybe the chart misses the real relation. But this isn't supporting evidence.

I agree that symptom count is a weird measure, and wouldn't expect it to show much, so r=0.4 is quite impressive. It would be great to see this work done measuring the overall symptom severity/burden on standing. Maybe there is something impressive to find here