Microvascular Dysfunction and Basal Membrane Thickening in Skeletal Muscle in ME/CFS and Post-COVID, 2025, Slaghekke et al

[Jonathan Edwards]

What I find complicated is that Systrom talks of low right atrial filling pressure. AV shunting should increase right atrial filling pressure.

 

[Snow Leopard]

What I find complicated is that Systrom talks of low right atrial filling pressure. AV shunting should increase right atrial filling pressure.

Isn't the increased venous compliance / low systemic vascular resistance also associated blood pooling hence lower filling pressure?

Varicose veins are associated with AV shunting for example. https://www.sciencedirect.com/science/article/pii/0741521486904118

 

[Eddie]

What I find complicated is that Systrom talks of low right atrial filling pressure. AV shunting should increase right atrial filling pressure.

I think the shunting is a different category to the low right atrial filling pressures not the cause. Most have low RAP but some seem to have a peripheral limitation of oxygen reaching or being used by the muscles.

 

[Jonathan Edwards]

Isn't the increased venous compliance / low systemic vascular resistance also associated blood pooling hence lower filling pressure?

It could be in a non-equilibrium state but it would not explain a baseline state of low right atrial pressure I don't think. I find it hard to see how it would explain poor muscle perfusion.