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Michael VanElzakker

Discussion in 'ME/CFS research news' started by Sunshine3, Dec 28, 2018.

  1. Hutan

    Hutan Moderator Staff Member

    Messages:
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    Location:
    Australia
    To save others googling -
    [11C]PBR28 is a TSPO radiotracer
    TSPO is translocator protein, a marker of activated glial cells expressed on mitochondrial membranes
    TSPO is a commonly used marker used to investigate neuroinflammation

    Elevated levels have been associated with migraine, and with poor short-term memory performance in set of twins discordant for memory performance, and with post-stroke patients and multiple sclerosis. There looks to be a flurry of studies using this technique.

    It's not without its difficulties though:
     
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  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Location:
    New Zealand
    Expanding on @Hutan's comments on the difficulties with TPSO — from Integrated MRI and [11C]-PBR28 PET Imaging in Amyotrophic Lateral sclerosis

    There's probably a baseline expression of TSPO also, e.g. in vascular endothelium, but this sounds to be sparse. See Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain.

    An endothelitis or BBB disruption might also contribute to increased avidity. See Impact of Endothelial 18-kDa Translocator Protein on the Quantification of 18F-DPA-714 (which is discussing a different tracer).

    See also [1] and [2] for more papers on TPSO.
     
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  3. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    735
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    New Zealand
    Michelle and Hutan like this.

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