Does Methylphenidate Reduce the Symptoms of Chronic Fatigue Syndrome?, 2006, Blockmans et al
There's this 2006 Belgium study.
There's this 2006 Belgium study.
The objectives of this study were to investigate the short-term effects of methylphenidate, an amphetamine derivative, on fatigue, concentration disturbances, and quality of life.
A double-blind randomized placebo-controlled crossover study was conducted in 60 patients
A clinical significant effect (≥33% improvement or CIS ≤76) on fatigue was achieved in 17% of patients, who were considered responders; on concentration in 22% of patients.
Conclusions
Methylphenidate at a dose of 2 × 10 mg/day is significantly better than placebo in relieving fatigue and concentration disturbances in a minority of chronic fatigue syndrome patients. Further studies are needed to investigate the long-term effects of this treatment.
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