Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al

Another thought about this paper. So far every ME metabolomics paper I've seen doesn't have a disease control. I'm very keen to see that because the metabolome is extremely dynamic and it seems plausible to me that effects like the one seen in this paper could be a knock on effect of something else. Maybe it's something commonly seen as a result on many pathological processes.

 

I read the first line and was thinking 'how bad could it be?' I wasn't expecting something that sounds so much like an aphrodisiac.

 

It’s actual shark liver oil no?
That seems like not something we’d wanna be grabbing on mass, given existing problems with over fishing and shark populations.

 

My reading is that the oil mostly comes from "dogfish" which is the shark they use for fish and chips. Apparently they're catching these fish anyway, they're pleased to be able to use the livers for something. What's more 25% of the weight of the shark is liver.

Happily, dogfish is not overfished
https://www.fisheries.noaa.gov/species/atlantic-spiny-dogfish

In my view it's not conceptually different from a lot of omega-3 supplements, but as I observed earlier, the name gives people pause.

 

Ahh I couldn’t work out what you meant. That sounds better.

Yeah, I heard there were problems with the other omega fish oils too. I guess also there is the problem of pollution in the ocean making these toxic too.

I don’t know what the answer is because people cannot necessarily manage on the less useful plant oils.

I definitely have had slight improvements when I did take Krill oils.

 

I have a 3 page report re RBC fatty acids, my omega 3 levels were at 3%. All the the others were within normal range. Taking plant based oils didn't work for me based on my results.

I take Webber triple Omega 3 fish oils b/c it's IVO My brain function had noticeably improved after taking omega 3 fish oils for 3 months.

 

Alkyrol—seems like this a Europe only product.

Europe…..

The best cheese, the best shark oil.

 

Related to peroxisomal function and a key product of the peroxisome, the plasmalogen:

Having considered this paper on plasmalogen replacement therapy I've bought shark liver oil and started taking a couple of tablets a day. The product I got is this one:

https://www.beevitamins.com.au/products/costar-shark-liver-oil-1000mg-365-capsules-australian-made

I don't just take any old supplement. This meets my criteria of being research-backed on both sides: plasmalogens are shown to be deficient in mecfs and this product category is shown to be beneficial in increasing plasmalogens. It's inexpensive and, being an animal fat, likely to be safe in modest doses.

Took them yesterday and certainly feel no worse today. Will report back on whether I notice anything material over the medium term.

As for all such endeavours it's most likely I won't be able to tell signal from noise, since the causation in the research is unclear, the product quality is unclear, and my background symptom variation is high enough to obscure all but the most significant changes.

 

Brave man . I imagine that if SLO provides any symptom relief you should know in about a month, as the Paul study noted significant increases in plasmalogens by 3 weeks.

 

Getting shark liver oil nightmares/lucid dreams. Apparently this is a thing:







https://bcr.org/2024/01/17/why-does-fish-oil-give-me-nightmares/