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Metabolism reprogrammed by the nitric oxide signalling molecule

Discussion in 'Health News and Research unrelated to ME/CFS' started by Andy, Dec 5, 2018.

  1. Andy

    Andy Committee Member & Outreach

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    https://www.nature.com/articles/d41586-018-07457-z
     
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  2. Hutan

    Hutan Moderator Staff Member

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    This is an interesting paper.

     
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  3. obeat

    obeat Senior Member (Voting Rights)

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    I think ME biobank are sending samples to an Austrian researcher investigating NOS?
     
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  4. Inara

    Inara Senior Member (Voting Rights)

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    That's indeed very interesting. Thank you @Andy for sharing.
     
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  5. Andy

    Andy Committee Member & Outreach

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  6. sb4

    sb4 Senior Member (Voting Rights)

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    @Hutan Very interesting. So we could speculate that we probably don't have much problems with ischaemia as this lack of oxygen would also result in problems with fat metabolism. Quite a few people with CFS/POTS do ok on fats but bad on carbs. So what would be causing the NO that then results in poor PDH function?

    Could it be some sort of pathogen or something in the gut? The body produces peroxynitrite to deal with pathogens, right?
     
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  7. Hutan

    Hutan Moderator Staff Member

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    Ischaemia - an inadequate blood supply to an organ or part of the body

    The work on blood cell deformability suggests that there is an inadequate supply of blood to some tissues due to problems with blood flow in the small capillaries.

    I don't know. It would take me a long time to work out if/how this might fit with what we suspect about ME. But maybe someone who knows more can do it.
     
  8. sb4

    sb4 Senior Member (Voting Rights)

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    @Hutan I do think there is a problem with blood getting places based on red cell deformity and my symptoms of pounding heart, feeling like it has to work harder to get the blood where it needs to be.

    Having said this though, fat needs more oxygen to burn than carbs. So if we where experiencing a lot of ischaemia then I would think people would do a lot worse on fat but this doesn't seem to be the case generally. This sort of implies that if PDH malfunction is caused by NO then it is not generated by ischaemia but something else. Obviously just wildly speculating here.
     
  9. Michelle

    Michelle Senior Member (Voting Rights)

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    @sb4 : Of course, there is a subset of us ME/CFS patients who do have a lot of problems with fats (I know @Sid on the other forum has talked about her problems with fats also). I would think the patients with comorbid gastroparesis would be having difficulties with fats too as they slow down digestion.

    Interesting study in light of some of the research going on, including Fluge and Mella's PDH paper a couple of years ago.
     
    Last edited: Dec 17, 2018
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  10. sb4

    sb4 Senior Member (Voting Rights)

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    @Michelle You are right about the gastropareses. In fact that is the reason I dont tolerate fats well. However the mechanism is differen't. As far as I am aware that actual metabolism of fat isn't a problem in as many people with CFS as is carb metabolism.
     
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