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Medical Express: Researchers identify key role of immune cells in brain infection (2020)

Discussion in 'Other health news and research' started by Ravn, Sep 20, 2020.

  1. Ravn

    Ravn Senior Member (Voting Rights)

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    In mice.
    https://medicalxpress.com/news/2020-09-key-role-immune-cells-brain.html

    An interesting bit from the very technical and way above my head paper the above is based on: immune cells get through the BBB into the brain even as the virus is being cleared by antiviral treatment, and the timing with which those immune cells arrive is awfully similar to my PEM. Most probably a coincidence, I don't have viral encephalitis nor am I a mouse, but just couldn't help noticing.
    Cell Reports: Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis (2020)
    https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31139-6?

    I did a very quick google of the 2 molecules investigated in the paper in relation to ME.
    Didn't find anything for CXCR2. But CXCL1 has cropped up in past studies (have only glanced at the abstracts):

    Cytokine signature associated with disease severity in chronic fatigue syndrome patients; Montoya; 2017
    https://pubmed.ncbi.nlm.nih.gov/28760971/

    And another one from the same stable: Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2018
    https://www.nature.com/articles/s41598-018-20941-w
    thread here: https://www.s4me.info/threads/value...nic-fatigue-syndrome-2018-montoya-et-al.2345/

    And a search on S4ME also brings up this: https://www.s4me.info/threads/the-r...ations-with-symptoms-2019-jonsjö-et-al.13063/
     
    Philipp, alktipping, rvallee and 12 others like this.

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