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MEA Research Update: Metabolomics and ME/CFS – Dr Morten and the Oxford research centre 13th August 2018

Discussion in 'General ME/CFS News' started by MeSci, Aug 13, 2018.

  1. MeSci

    MeSci Senior Member (Voting Rights)

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    The ME Association has been working for some time with Dr Karl Morten and the research team at Oxford who have recently been honing their approach to the study of metabolomics in ME/CFS.

    Before embarking on a new study utilising samples from the ME/CFS Biobank for the ME Association, they have been conducting research using samples from a patient cohort in Poland.

    https://www.meassociation.org.uk/20...-the-oxford-research-centre-13th-august-2018/
     
  2. strategist

    strategist Senior Member (Voting Rights)

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    Interesting stuff.

    A mysterious metabolite came up in their analysis.

    I don't understand what they did here exactly but it seems that whatever kind of exercise this was didn't affect the metabolic alterations. I remember that least year they reported that GET appeared to have a negative impact on energy production. It sounds like this was a CPET, in which case it has nothing to do with GET.

     
  3. Trish

    Trish Moderator Staff Member

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    It looks like they have some really interesting findings already including differences between pwME and healthy controls. It's great that they had access to a lot of clinical data and blood samples from a Polish clinic. That meant they could relate the blood metabolites to things like tilt table test data and exercise data. They are looking at subgrouping, and picking the most interesting metabolites to look at in the much larger set of samples from the UK ME biobank, with the hope of finding biomarkers.

    That mysterious unidentified metabolite has me intrigued. I guess there are so many possible organic molecules, not all are in the databases.

    Exciting stuff.
     
  4. MeSci

    MeSci Senior Member (Voting Rights)

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    Doesn't this conflict with what Ron Davis found? I can't think where it is - I think it's on this site somewhere, and also on Phoenix Rising - he found a lot of differences.
     
  5. strategist

    strategist Senior Member (Voting Rights)

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    This research found differences between patients and controls, but no differences when comparing metabolic profiles of patients before and after an exercise stress test (it is a bit unclear what they did exactly, but that's my interpretation).

    Hanson et al is doing similar work but hasn't published yet I believe.
     
    Last edited: Aug 13, 2018
  6. Amw66

    Amw66 Senior Member (Voting Rights)

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    How soon after exercise was the analysis done - 24/48/72 hours?
    The delay in PEM may be of importance. Were the subjects experiencing this when tbe second bloods were done?

    Could the unknown metabolite be the " something in the serum ?"

    Lots of questions
     
  7. strategist

    strategist Senior Member (Voting Rights)

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    Good question.
     
  8. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    I've often wondered if the two-day CPET is really long enough of a delay to capture PEM. My PEM seems to become more delayed the longer I've had ME.
     
  9. Daisybell

    Daisybell Moderator Staff Member

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    I’m looking forward to the actual paper coming out - as long as I can make sense of it...!
     

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