ME researcher Jonas Bergquist - interviews, talks

"Utnyttja kompetensen vi byggt upp på humansidan"
https://www.slu.se/fakulteter/vh/forskning/gastprofessorer/jonas-bergquist/

Google Translate, English ("Utilise the skills we have built up on the human side")

Lovely interview :):thumbsup:

:emoji_horse:
Auto-translate said:
A unique, multi-year series of measurements on racehorses is the basis for one of the projects that visiting researcher Jonas Bergquist is helping to investigate. The question here is whether biochemical markers can tell us whether a horse is becoming overtrained - or stronger. Jonas Bergquist brings the analysis methods from the human side.
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Auto-translate said:
When Jonas Bergquist is asked to highlight something from his career that feels particularly important, he chooses the work with patients affected by ME, myalgic encephalomyelitis (also known as chronic fatigue syndrome) from the human side.

- This is a patient group that is completely forgotten. The phenomenon has been known for a hundred years and there is a large group affected. Now that we unfortunately see that many people are suffering from long-term sequelae of COVID-19 infection, the topic is even more relevant.

Here too, the attitude that it is beautiful to be able to measure comes in handy. It is also important to know exactly where and how to take samples. For horses, it is plasma and analyses through proteomics and metabolomics that will provide the answer.

For ME sufferers, lumbar puncture, among other things, provides answers. It is important to find the right method.
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Auto-translate said:
How many animals do you have?

- In the family we have a Spanish water dog, two private horses and we run a stable with some other families with 25 horses. There are also four barn cats.
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mango said:
Analysis of tryptophan metabolites and related compounds in human and murine tissue: development and validation of a quantitative and semi-quantitative method using high resolution mass spectrometry
https://pubs.rsc.org/en/content/articlelanding/2024/ay/d3ay01959d
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From OMF email newsletter:

Research Summary: From the Desk of Dr. Jonas Bergquist:

“Our recent study, published in the Analytical Methods Journal, aimed to investigate the levels of tryptophan metabolites in human plasma using an advanced technique called high-resolution mass spectrometry. Tryptophan is an essential amino acid that plays a crucial role in various metabolic processes. Disruptions in its pathway have been implicated in several diseases.

Our goal is to incorporate this methodology in our upcoming study to analyze plasma samples from people diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and comparing them to samples from healthy individuals, to uncover potential mechanisms involved in the development of this debilitating disease. This study supports the Kynurenine trap model for ME/CFS, shedding light on the pathogenesis of the condition. We hope that our findings will contribute to a deeper understanding of ME/CFS.”
 
Video interview, 5 minutes long, in Swedish. Published by RME.

He talks a bit about the LIFT study (a combination of LDN and mestinon), and the so called "home visit study" (the the data collection and analysis is done, they are working on the statistics part now. They have found that mitochondrial markers such as lactate, and some cell metabolism markers, are significantly altered.)

 
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