Moderator note: This post and the next two have been copied, and subsequent posts moved from this thread: JAMA -"Advances in understanding the Pathophysiology of Chronic Fatigue Syndrome" by Anthony Komaroff That’s a good list and I’m sure that’s the right way to go to really interest people in the field. I think two other findings are worth adding to the list: The fact that, consistently, around 80% of patients are women. This is pretty unusual, I think. And while more females receive a mental health diagnosis, I thought that typically this was around 2/3, rather than the 80% same for any CFS. Also, the remarkable “two peaks“ age profile of the honours, with the first peak in adolescence/early adult hood (with the gender difference emerging during puberty) in the second pic starting in people‘s thirties. It’s hard to explain this finding, but it surely a sign that something unusual is going on here.