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ME/CFS and the immune system. Where are we now?Geraldine (Jo) Cambridge, PhD, Dep

Discussion in 'BioMedical ME/CFS News' started by Sly Saint, Dec 19, 2017.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    [​IMG]
    RME Sverige

    Published on Dec 19, 2017
    Geraldine (Jo) Cambridge, PhD, Dep. Medicine, University College, London on B-cell depletion with Rituximab.

     
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  2. Invisible Woman

    Invisible Woman Senior Member (Voting Rights)

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    The presentation itself is about 26 minutes and then there is discussion.
     
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  3. Billt

    Billt Established Member

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    Thanks for sharing this
     
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  4. ukxmrv

    ukxmrv Senior Member (Voting Rights)

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    It seems to have been recorded before the sad announcement about the Rituximab study
     
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  5. Marco

    Marco Senior Member (Voting Rights)

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    "We are here" (finally)

    "ME/CFS is an organic disease" (@ 2:27)

    Very gratifying to hear but I wonder what evidence Jo Cambridge is basing this statement on?
     
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  6. BurnA

    BurnA Senior Member (Voting Rights)

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    Yes, I'd like to know what her thoughts are now.

    It was interesting that they did show differences between patients and HCs for some tests.
    Also she mentioned collaboration with Carmen Scheibenbogen in Berlin and being excited about something she is doing.
     
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  7. Invisible Woman

    Invisible Woman Senior Member (Voting Rights)

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    My take on it (what I hope it means) is that although Ritux itself is not going to be "The Cure", the team will have made some useful discoveries along the way that could provide useful information to J Cambridge and others.

    This information might provide clues as to where to look next and may provide a stepping stone for other research.
     
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  8. JamBob

    JamBob Established Member

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    One of the things I was most worried about when I heard the news about the negative trial results was that we would lose our fab UCL team - Jo Cambridge and Fane Mensah (and our lovely advisor Jo Edwards) as I was under the impression the research at UCL was focused around laying the groundwork for the forthcoming (obviously not now) Rituximab UK trial.

    Is it likely UCL will abandon ME research now that Rituximab treatment is shown not to work for ME or does anyone know if the UCL team is still interested in studying this disease. Also what would happen to Fane's Phd if he was studying B cells in ME but it turns out they aren't the problem - would he have to do the whole thing again? He seems like such a decent guy and it was great that we had a young researcher interested to help in our disease - if B cells haven't worked out - would he keep studying it?
     
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  9. Invisible Woman

    Invisible Woman Senior Member (Voting Rights)

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    A good question @JamBob .

    Ritux aside, from Jo Cambridge's presentation I understood they have found a problem with B cells - specifically CD21 & CD24 molecules. The observations made by the UCL team may indicate some mitochondrial problem. I don't really understand the science. So, although Ritux may not be the answer, B cells may well still be part of the problem, or a symptom of the problem.

    I should imagine/hope Fane Mensah's work still stands. He is adding to the overall knowledge we have of how these things work.

    I seem to remember seeing somewhere that the Norwegian team have indicated that they are still interested in studying ME/CFS. We will probably have to wait until they are ready to publish to find out more.

    I would love to hear @Jonathan Edwards take on where we are now and what he believes is likely to happen next.
     
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