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Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C, 2018, Rosen et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Andy, Jan 28, 2018.

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  1. Andy

    Andy Committee Member & Outreach

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    Paywalled at http://www.pnas.org/content/115/3/E478
     
    Andy, Jan 28, 2018
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  2. James

    James Established Member (Voting Rights)

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    James, Jan 28, 2018
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  3. Helen

    Helen Senior Member (Voting Rights)

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    Helen, Jan 28, 2018
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  4. Andy

    Andy Committee Member & Outreach

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    Andy, Jan 30, 2018
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  5. wastwater

    wastwater Senior Member (Voting Rights)

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    I found a B cell and leukaemia link for myself as the genetic locations mentioned on Ulf Klein (Leeds) Page are likely my genetic locations Axenfeld rieger syndrome that contains autism and mecfs
    Research Mention of non Hodgkin lymphoma as well
    FOXC1/FOXO1A
    Zinc/G protein receptor 39 mentioned as well
     
    Last edited: Feb 2, 2018
    wastwater, Jan 31, 2018
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  6. janice

    janice Established Member (Voting Rights)

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    Last edited: Jan 31, 2018
    janice, Jan 31, 2018
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  7. Trish

    Trish Moderator Staff Member

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    Hi @janice, thank you for the link. It's useful if you also give the title, date and author, and you can copy an abstract, but not a whole paper.

    Your first two links gave me error messages, the third linked to this. I've broken it up for ease of reading:

    Mini Review by Song Liu et al.

    Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

    Abstract

    Recent studies have revealed the diverse pathophysiological functions of mitochondria beyond traditional energetic metabolism in cells.

    Mitochondria-released damage-associated molecular patterns, particularly mitochondrial deoxyribonucleic acid (mtDNA), play a central role in host immune defenses against foreign pathogens.

    Newly discovered cGAS-STING signaling is responsible for microbial DNA recognition, and potentially participates in mitochondrial DNA sensing.

    Inappropriate inflammatory signaling mediated by mtDNA is implicated in various human diseases, especially infectious/inflammatory disease and cancer.

    In addition, mtDNA horizontal transfer between tumor cells and surrounding somatic cells has been recently observed and been associated with tumorigenesis and cancer progression.

    In this review, we will summarize the molecular signaling of mtDNA recognition (especially STING signaling), and discuss the underlying mechanism by which mtDNA transfer triggers cancer progression in human.

    Besides, we will highlight the central role of mtDNA in host immunity, with particular emphasis on mtDNA-induced NETs (neutrophil extracellular traps) formation, apoptosis and autophagy.

    http://onlinelibrary.wiley.com/doi/...riods+of+downtime+or+disruption+in+the+future.
     
    Trish, Jan 31, 2018
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  8. janice

    janice Established Member (Voting Rights)

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    Thanks @Trish hopefully I can get that to stay in my foggy brain and so make use of it next time. Fingers crossed!
     
    janice, Feb 1, 2018
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  9. janice

    janice Established Member (Voting Rights)

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    I found this a useful review to get to know the background of recent Immunological advances.

    It has the advantage of being in a high impact paper and again has lots of useful refs.

    Plus mentions of T and B cell homeostasis, PAMPS, DAMPS, etc which I found very helpful to get context.

    J Immunol. 2012 July 1; 189(1): 15–20. doi:10.4049/jimmunol.1102108.

    "Autophagy – an emerging immunological paradigm"

    Author : Vojo Deretic* of Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences
    Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA

    Abstract
    Autophagy is a fundamental eukaryotic process with multiple cytoplasmic homeostatic roles, recently expanded to include unique standalone immunological functions and interactions with nearly all parts of the immune system.

    Here, we review this growing repertoire of autophagy roles in innate and adaptive immunity and inflammation.

    Its unique functions include cell-autonomous elimination of intracellular microbes facilitated by specific receptors.

    Other intersections of autophagy with immune processes encompass effects on inflammasome activation and secretion of its substrates including IL-1β, effector and regulatory interactions with Toll-like and Nod-like receptors, antigen presentation, naïve T cell repertoire selection, and mature T cell development and homeostasis.

    Genome wide association studies in human populations strongly implicate autophagy in chronic inflammatory disease and autoimmune disorders.

    Collectively, the unique features of autophagy as an immunological process and its contributions to other arms of the immune system represent a new immunological paradigm.

    I know it's a bit old 2012 and so many has been used before?

    Anyway I hope it helps?
     
    janice, Feb 1, 2018
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