Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C, 2018, Rosen et al

Paywalled at http://www.pnas.org/content/115/3/E478

 

University site gives a little background:

https://liu.se/en/news-item/nytt-varningssystem-upptackt-i-kroppens-immunforsvar

 

Some of you might recall that Professor and immunochemist Anders Rosén got interested in ME/CFS after his retirement, when Prof. Jonas Blomberg introduced him to the disease. He was one of the speakers at a ME seminar in Sweden 2016. Happy to have him working for us.

About the latest study in Science:
http://www.sciencemag.org/news/2018/01/white-blood-cells-launch-dna-webs-warn-invaders

 

Just spotted on ResearchGate that Rosen has listed a project with the goal of "Role of mtDNA in leukemia and myalgic encephalomyelitis/chronic fatigue syndrome", so he obviously suspects, at least, some involvement of this process in ME. https://www.researchgate.net/project/Mitochondrial-DNA-web-casting-lymphocytes

 

I found a B cell and leukaemia link for myself as the genetic locations mentioned on Ulf Klein (Leeds) Page are likely my genetic locations Axenfeld rieger syndrome that contains autism and mecfs
Research Mention of non Hodgkin lymphoma as well
FOXC1/FOXO1A
Zinc/G protein receptor 39 mentioned as well

 

I found an open paper from 2016 which might give some useful background and refs?

https://www.ncbi.nlm.nih.gov/pubmed?cmd=historysearch&querykey=10

The above doesn't look right?

How about
PMID: 26939583 or DOI: 10.1002/ijc.30074

or
Int J Cancer. 2016 Aug 15;139(4):736-41. doi: 10.1002/ijc.30074. Epub 2016 Mar 25

As obviously I don't know how to give correct/useful citation? All helpful suggestions would be great. Really.

 

Hi @janice, thank you for the link. It's useful if you also give the title, date and author, and you can copy an abstract, but not a whole paper.

Your first two links gave me error messages, the third linked to this. I've broken it up for ease of reading:

Mini Review by Song Liu et al.

Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

Abstract

Recent studies have revealed the diverse pathophysiological functions of mitochondria beyond traditional energetic metabolism in cells.

Mitochondria-released damage-associated molecular patterns, particularly mitochondrial deoxyribonucleic acid (mtDNA), play a central role in host immune defenses against foreign pathogens.

Newly discovered cGAS-STING signaling is responsible for microbial DNA recognition, and potentially participates in mitochondrial DNA sensing.

Inappropriate inflammatory signaling mediated by mtDNA is implicated in various human diseases, especially infectious/inflammatory disease and cancer.

In addition, mtDNA horizontal transfer between tumor cells and surrounding somatic cells has been recently observed and been associated with tumorigenesis and cancer progression.

In this review, we will summarize the molecular signaling of mtDNA recognition (especially STING signaling), and discuss the underlying mechanism by which mtDNA transfer triggers cancer progression in human.

Besides, we will highlight the central role of mtDNA in host immunity, with particular emphasis on mtDNA-induced NETs (neutrophil extracellular traps) formation, apoptosis and autophagy.

http://onlinelibrary.wiley.com/doi/...riods+of+downtime+or+disruption+in+the+future.

 

Thanks @Trish hopefully I can get that to stay in my foggy brain and so make use of it next time. Fingers crossed!

 

I found this a useful review to get to know the background of recent Immunological advances.

It has the advantage of being in a high impact paper and again has lots of useful refs.

Plus mentions of T and B cell homeostasis, PAMPS, DAMPS, etc which I found very helpful to get context.

J Immunol. 2012 July 1; 189(1): 15–20. doi:10.4049/jimmunol.1102108.

"Autophagy – an emerging immunological paradigm"

Author : Vojo Deretic* of Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences
Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA

Abstract
Autophagy is a fundamental eukaryotic process with multiple cytoplasmic homeostatic roles, recently expanded to include unique standalone immunological functions and interactions with nearly all parts of the immune system.

Here, we review this growing repertoire of autophagy roles in innate and adaptive immunity and inflammation.

Its unique functions include cell-autonomous elimination of intracellular microbes facilitated by specific receptors.

Other intersections of autophagy with immune processes encompass effects on inflammasome activation and secretion of its substrates including IL-1β, effector and regulatory interactions with Toll-like and Nod-like receptors, antigen presentation, naïve T cell repertoire selection, and mature T cell development and homeostasis.

Genome wide association studies in human populations strongly implicate autophagy in chronic inflammatory disease and autoimmune disorders.

Collectively, the unique features of autophagy as an immunological process and its contributions to other arms of the immune system represent a new immunological paradigm.

I know it's a bit old 2012 and so many has been used before?

Anyway I hope it helps?