Trial Report Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy, 2025, Ruan et al

[Hutan]

but it does give a ceiling to how large the effect might be.

Yeah, that's pretty clear, thanks @ME/CFS Skeptic. There's really nothing there beyond what you'd expect from a placebo, natural fluctuations, and more than half of your cohort (probably the cohort with the least improvement) dropping out.

I did like the ATG13 work. I haven't read this study and I'm hazy on the previous work now, but do people think there is a way that finding might still be worth investigating?

 

[wigglethemouse]

I did like the ATG13 work. I haven't read this study and I'm hazy on the previous work now, but do people think there is a way that finding might still be worth investigating?

Putrino's lab with funding from PolyBio is running another trial. I was really disappointed that Amy Proal/PolyBio are reposting success stories on X of people posting a good response to Rapamycin and no poor responses.

 

[wigglethemouse]

Would be interesting to see the results for the Sf-36 physical functioning scale but it seems they haven't plotted that one (although it was measured).

I seem to remember the oxaloacetate trial paper promoted one of the physical function scales in the text of the paper vs the other which had null results (hope I'm remembering right). Sure would be nice to see Sf-36 data. Some of the same clinicians took part in the oxaloacetate and rapamycin open label trials.