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Low blood lactate

Discussion in 'Laboratory and genetic testing, medical imaging' started by strategist, Mar 16, 2022.

  1. strategist

    strategist Senior Member (Voting Rights)

    0.91 mmol/L with a reference range of 0.9 to 1.7

    Technically not yet low, but close enough.

    Is this a suspicious result? Aren't people with ME/CFS supposed to tend towards increased lactate levels?
    Chezboo, MeSci, Lisa108 and 1 other person like this.
  2. Lisa108

    Lisa108 Senior Member (Voting Rights)

  3. borko2100

    borko2100 Senior Member (Voting Rights)

    Yes it is logical that it should be higher. But I just a read study that said that half of the participants had normal lactate at rest. I think lactate abnormality should be more pronounced when exercising. And even more when comparing CPET tests. Another study showed no lactate reduction on the second CPET in people with ME, but a reduction in controls (which would be expected of course).
    alktipping and Hutan like this.
  4. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

    alktipping likes this.
  5. Hutan

    Hutan Moderator Staff Member

    I bought a lactate monitor, one with paper strips to soak up blood from a fingerprick and a monitor that gives a read-out. I tested my blood at rest, at time intervals after short periods of intense exercise, and when I felt good and when I had PEM and felt as though my body was crushed and my muscles were fatigued.

    And I didn't find anything abnormal.

    (Edit - but when doing a 2xCPET in a study, I did show the typical ME/CFS reduction in output at ventilatory threshold etc on the second test.)
    Last edited: Mar 16, 2022
  6. Ryan31337

    Ryan31337 Senior Member (Voting Rights)

    For what it's worth I had 2x blood lactate tests in an outpatients myopathy clinic.

    For the first I was told I had the highest result the doc had seen outside of ICU, 7.4 with normal range 0.6 - 2.0. Other refs I found suggested it was on par with what you'd see post-marathon. The repeat test a few months later was high-normal.

    I was experiencing PEM on the first day. Before the test I'd walked 5-10mins from the train station and went up several flights of steps to the point of burning muscles and needing to use my arms to get up them (a rapid onset of that was always obvious on a "bad day"). That trip was the only thing I'd done all day, certainly no 'exercise', and I wasn't sick (no more than usual).

    The second trip I was well rested, without PEM, though the train journey and walk was always still enough to do me in the next day, it just didn't impart the immediate issues.

    I did get a muscle biopsy off the back of that first result. Unfortunately I was never that satisfied with the follow-up, it took months of chasing to get a report saying "There is a possibility of mitochondrial changes but the staining needs to be repeated due to some technical issues". After more months of chasing the lab apparently confirmed there were only mild, non-specific changes after all, but I never saw any written report and it sounds like someone messed something up, so who knows if it did ever get properly analysed. Unfortunately the negative biopsy meant no genetic screening & I was discharged, so dead end.
    Sid, Snow Leopard, borko2100 and 4 others like this.
  7. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    If you have been avoiding intense activity, your lactate levels should be on the low side.
    FMMM1, Mij, Wonko and 2 others like this.
  8. Wonko

    Wonko Senior Member (Voting Rights)

    And if it's impossible to avoid intense activity coz sometimes I need to get a drink.......or use the bathroom.....

    Of course opening the curtains is right up there, requiring leaning bent over on things to recover enough to sit/lie down....

    My point us...intense activity is relative.
    FMMM1, Ryan31337 and NelliePledge like this.

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