Landmark national trial to examine how exercise affects your body — down to your molecules

[rvallee]

Although this shows how, yet again, the NIH misses every opportunity to show its commitments to us, it could still provide useful clues and a good comparison base for exercise studies. In particular it will focus on deconditioned participants and compare them to highly active individuals. This should put to rest the nonsense about deconditioning and how deconditioned people actually respond to exercise. Not that I expect that trope to be abandoned but still.

It also shows the money is there if the will is there, in the form of the NIH common fund.

I wonder if there would be a way for some ME researchers focused specifically on exercise as a trigger to get involved. The NIH did not think of us here where they should obviously have but maybe it's not too late to leverage it.

What happens at the molecular level after exercise? Scientists, physicians and clinical exercise specialists from across the country are embarking on a landmark National Institutes of Health effort to find out.

The goal of the Molecular Transducers of Physical Activity Consortium, known as MoTrPAC, is to create a comprehensive map of the molecular responses to exercise and its relation to health.

The study, funded by a $240 million program through the NIH Common Fund, will enroll 1,980 adults across 10 clinical sites and 300 children at one site. Along with UAB, sites include: Ball State University, Muncie, Indiana; Duke University, Durham, North Carolina; East Carolina University, Greenville, North Carolina; AdventHealth, Orlando, Florida; the University of California, Irvine; the University of Pittsburgh; the University of Colorado, Denver; University of Texas Medical Branch at Galveston; Pennington Biomedical Research Center at Baton Rouge; and University of Texas Health Science Center at San Antonio.

Most of the study participants will be people who do not exercise regularly. They will be divided into three groups: 840 who will do endurance exercise; 840 who will do resistance exercise; and 300 who will not do either. Participants in both exercise groups will receive personal coaching.

There will also be a comparison group consisting of 300 people considered highly active or trained, meaning they have been consistently sticking to endurance training or resistance training for the past year or longer.

Scientists will assess participants’ cardiorespiratory function, muscular strength and body composition. Researchers will also collect blood, muscle and fat samples, monitor participants’ free-living physical-activity level using wearable devices, and complete participant-reported outcomes and health status by interviews and questionnaires.

https://www.uab.edu/news/research/i...cise-affects-your-body-down-to-your-molecules