Marshall-Gradisnik's group does small studies, releases PR posts that say they've found 'the answers to ME' (with a heading titled First Proof CFS/ME is a Real Thing!) and moves on to another small study without ever returning to validate the first. I think her group's work is fine, and I have a hard time faulting them for 'following the money' when funding for ME research is so devilishly hard to secure. But with no validation or replication, it's impossible to tell if these were non-findings when they expanded their pool, or if they didn't try again, or if they tried to get funding for larger studies and were denied. I don't think we're wrong to be looking into immune function! However, their work is not proof of T cell involvement. I know others who are doing T cell work, and hope that they are able to replicate with larger numbers of patients.