Is hereditary alpha-tryptasemia behind MCAS/dysautonomia/hEDS cases?

The NIH has a page on this:

https://www.niaid.nih.gov/research/hereditary-alpha-tryptasemia-faq

(I edited this so that it quotes the NIH directly)

 

@Chris Ponting this will interest you.

 

Thanks for posting this @strategist .

It’s interesting that the Ontario working group also looked at MCAS as well as ME and fibromyalgia.
https://www.s4me.info/threads/canad...ke-announcement-regarding-me-august-22.10919/

 

As far as I can see this page tells us nothing useful. Almost every sentence includes 'may' this or 'may' that. A number of statements suggest that whoever is writing it does not really understand what is science and what is hearsay. I suspect that as in the UK government bodies like NIH are increasingly allowing all sorts of doubtful stuff to be put up on webpages. The scramble to be patient friendly has led to nobody trying to tease out the facts from the garbage.

The page seems to say that it is not known whether the tryptase level has anything to do with mast cells. I don't see what it would have to do with dysautonomia. And I don't think there is any evidence for a genetic link to hEDS.