1. Guest, the 'News in Brief' for the week beginning 19th September 2022 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate Viral Replication, 2021, Ren et al

Discussion in 'Other health news and research' started by Andy, Sep 15, 2021.

Tags:
  1. Andy

    Andy Committee Member

    Messages:
    17,457
    Location:
    Hampshire, UK
    Abstract

    Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus (H1N1), a single-stranded, negative-sense RNA virus with an eight-segmented genome, enhanced glycolysis both in mouse lung tissues and in human lung epithelial (A549) cells.

    In detail, the expression of hexokinase 2 (HK2), the first enzyme in glycolysis, was upregulated in H1N1-infected A549 cells, and the expression of pyruvate kinase M2 (PKM2) and pyruvate dehydrogenase kinase 3 (PDK3) was upregulated in H1N1-infected mouse lung tissues. Pharmacologically inhibiting the glycolytic pathway or targeting hypoxia-inducible factor 1 (HIF-1), the central transcriptional factor critical for glycolysis, significantly reduced H1N1 replication, revealing a requirement for glycolysis during H1N1 infection.

    In addition, pharmacologically enhancing the glycolytic pathway further promoted H1N1 replication. Furthermore, the change of H1N1 replication upon glycolysis inhibition or enhancement was independent of interferon signaling. Taken together, these findings suggest that influenza A virus induces the glycolytic pathway and thus facilitates efficient viral replication. This study raises the possibility that metabolic inhibitors, such as those that target glycolysis, could be used to treat influenza A virus infection in the future.

    Open access, https://link.springer.com/article/10.1007/s12250-021-00433-4
     
    Skycloud, alktipping, ukxmrv and 8 others like this.
  2. Lidia Thompson

    Lidia Thompson Established Member (Voting Rights)

    Messages:
    50
    Location:
    Leeds
    Keto diet?
     
    DokaGirl likes this.

Share This Page