SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19 Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin;...
Redefining the role of Hypoxia-inducible factors HIFs in oxygen homeostasis Clemente Fernández Arias; Franciso J Acosta; Federica Bertocchini;...
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time...
Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia...
Lactate is a glycolysis product that is produced from pyruvate by LDH (lactate dehydrogenase) and plays an important role in physiological and...
Role of miR-2392 in driving SARS-CoV-2 infection J. Tyson McDonald; Francisco J. Enguita; Deanne Taylor; Robert J. Griffin; Waldemar Priebe; Mark...
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts Joseph W. Guarnieri; Joseph M. Dybas; Hossein...
Abstract Previous studies have shown that monocytes can be ‘trained’ or tolerized by certain stimuli to respond stronger or weaker to a secondary...
Abstract Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In...
Highlights • PDH activation suppresses cell proliferation by reducing the NAD+/NADH ratio • Insufficient ATP demand slows mitochondria NAD+...
Abstract Although understanding of the biomedical basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is growing, the underlying...
I wonder whether this anything to do with ME/CFS. These data argue that cells engage in aerobic glycolysis when the NAD+ demand for oxidation...
So there is some evidence for impairment of glycolysis in pwME, leading to use of other fuel sources. I'm curious as to what the practical...
Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and...
Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in...
Basal glycolysis is reduced in ME/CFS CD4+ T cells. https://www.jci.org/articles/view/132185/figure/4 paper from December 2019...
Abstract BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is medically unexplained post-exertional fatigue associated with...
George Brooks has been trying to reshape thinking about lactate—in the lab, the clinic and on the training field—for more than 40 years, and...
This might be of background interest for some. The brain’s energy demands are remarkable both in their intensity and in their moment-to-moment...
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