Science - following Karl Popper - gave up the notion of 'proof' - science has moved to a position of conditionality, that is there is no absolute only the continuing standard of falsification, which provides that so long as an hypothesis is falsifiable, and has been subject to tests of falsifiability that hypothesis remains a scientifically valid description of the phenomenon it is concerned with, until such time as it is falsified. Everything remains on the table and everything can be revisited with new testing.In the 15th and 16th centuries, Nicolaus Copernicus and Galileo Galilei also put forward a theory that did not fit the then understanding of science. These theories were not finally proven until the 20th century,
The key point is that the hypothesis (or theory) must be capable of falsification - if it is not falsifiable it can not be subject to a meaningful scientific test and there is no value considering it in the context of science. There are other ways to consider things - art, religion etc, but those are not scientific unless they involve testable falsifiability.
Popper's proposition: https://staff.washington.edu/lynnhank/Popper-1.pdf
"When should a theory be ranked as scientific?" or "Is there a criterion for the scientific character or status of a theory?
The problem which troubled me at the time was neither, "When is a theory true?" nor "When is a theory acceptable?" my problem was different. I wished to distinguish between science and pseudo-science; knowing very well that science often errs, and that pseudoscience may happen to stumble on the truth."