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Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in CFS, 2018, Barnden et al

Discussion in 'ME/CFS research' started by Indigophoton, Jul 17, 2018.

  1. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    adambeyoncelowe and Inara like this.
  2. Daisymay

    Daisymay Senior Member (Voting Rights)

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    Thanks for your interpretations. Do you know of any research on what causes such loss in myelin in the brain/brainstem?
     
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  3. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    No, it is not an area I know about in detail.
     
  4. NelliePledge

    NelliePledge Moderator Staff Member

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    maybe @Woolie would have info?
     
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  5. Hoopoe

    Hoopoe Senior Member (Voting Rights)

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  6. lansbergen

    lansbergen Senior Member (Voting Rights)

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  7. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    Michael's response is very interesting too:

    https://twitter.com/user/status/1030930651455913985


    He talks about how the part of the brain highlighted in this study 'samples' circulating cytokines, and links everything to astrocytes and microglia.

    I definitely get the sense that we're onto something that might be elucidated soon.
     
    merylg, Indigophoton, Webdog and 7 others like this.
  8. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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  9. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    Johanna WJ, merylg, Simone and 3 others like this.
  10. Inara

    Inara Senior Member (Voting Rights)

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    I understood in the paper, indeed, the brainstem signal wasn't quite expected, so maybe they were hoping to find something else but found this. If I remember correctly they are suggesting another technique to follow this up. So, taken together, another study should go on as Michael vanElzekker suggests?
     
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  11. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    I think so. I'm trying not to get excited but it looks interesting.
     
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  12. Inara

    Inara Senior Member (Voting Rights)

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    Thanks for these Twitter posts. Quite interesting!

    Edit: Does this mean there could be a leaking blood brain barrier?
     
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  13. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    I'm not seeing the last tweet you posted(?)
     
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  14. Trish

    Trish Moderator Staff Member

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    I think he must have deleted it from Twitter.
     
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  15. MSEsperanza

    MSEsperanza Senior Member (Voting Rights)

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    Thank you, @adambeyoncelowe . Sounds really interesting. But what are "EVs"?
     
  16. Inara

    Inara Senior Member (Voting Rights)

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    Enteroviruses?
    I can't see the twitter post either.
     
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  17. Amw66

    Amw66 Senior Member (Voting Rights)

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    when clicked to twitter message is that page does not exist
     
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  18. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    It's been deleted from Twitter. He said they may be a cause for a minority, but that's it. I know he theorises that neurotropic viruses can infect the vagus nerve, and he thinks the brainstem changes are around/near that point.
     
  19. MSEsperanza

    MSEsperanza Senior Member (Voting Rights)

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    seems to have just moved:
    https://twitter.com/user/status/1030932218233860096
     
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  20. Pechius

    Pechius Senior Member (Voting Rights)

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