Hi A friend mentioned to me that they were considering using a new supplement* that others say has helped people with ME. She was confident that there was a good body of university-led research to support it. When I asked if she had verified that best practice was used for each of those research papers, she asked me how she could tell if it was good quality research. Well, I realised that I couldn't give her a list of things to look out for! - other than the assessments I have read of the PACE trial that have highlighted issues with that research. I wondered what people here look for when reviewing new research papers? Does anyone have a checklist that they use to assess the quality of the research process and reliability of the research results? Is there already a thread here on S4me for this? *fyi supplement under her consideration is Protandium. And there is a thread on here that I have shared with her https://www.s4me.info/threads/protandim.11453/ A quick google and I found a few documents, and have stopped at WHO... World Health Organization - Recommended format for Research Protocols This document contains their guidelines for submissions of Research Proposals to WHO. So it is a research preparation list, not a research review list. And some is related to protecting the human participants, more than guaranteeing a quality research outcome. But perhaps will do? https://www.who.int/ethics/review-committee/format-research-protocol/en/ Also found the WHO GCP (Good Clinical Research Practice) statement - which at 129 pages is not quite the short list I was after https://www.who.int/medicines/areas/quality_safety/safety_efficacy/gcp1.pdf Summary of Info from the WHO Research Protocol format page... Clarity in what is written up would be important to. Before I spent more time, I thought I would throw the question out here. What do you look out for when reviewing a research paper?