Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue, 2020, Li

Dolphin · May 5, 2020

https://www.sciencedirect.com/science/article/pii/S0168010220301577

Neuroscience Research
Available online 30 April 2020
In Press, Journal Pre-proof What are Journal Pre-proof articles?

Research Paper
Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue

Danxi Li ab1
Di Hu b1
MikaShigetabYutaOchibYasuyoshiWatanabebFengLiaYilongCuib
https://doi.org/10.1016/j.neures.2020.04.005
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Highlights

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Body temperature adaptively increased in response to fatigue loading initially

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Increment of body temperature unable to retain in late phase of chronic fatigue load

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Frequency of tail heat dissipation dynamically changed with advances in fatigue load

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Body temperature for heat dissipation dived under that for non-dissipation with time
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Abstract

Chronic fatigue syndrome (CFS) is characterized by long-lasting fatigue, and a range of symptoms, and is involved in homeostasis disruption.

CFS patients frequently complain of low grade fever or chill even under normal body temperature indicating that thermosensory or thermoregulatory functions might be disturbed in CFS.

However, little is known about the detailed mechanisms.

To elucidate whether and how thermoregulatory function was altered during the development of chronic fatigue, we investigated temporal changes in body temperature with advance of fatigue accumulation in a chronic fatigue rat model using a wireless transponder.

Our findings demonstrated that the body temperature was adaptively increased in response to fatigue loading in the early phase, but unable to retain in the late phase.

The tail heat dissipation was often observed and the frequency of tail heat dissipation gradually increased initially, then decreased.

In the late phase of fatigue loading, the body temperature for the tail heat dissipation phase decreased to a value lower than that for the non-dissipation phase.

These results suggest that adaptive changes in thermoregulatory function occurred with fatigue progression, but this system might be disrupted by long-lasting fatigue, which may underlie the mechanism of fatigue chronification.
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Andy · May 5, 2020

Paper not currently available via Sci hub.

Chances are their chronic fatigue rat model is simply a rat exhausted via over exercise, so the value of the findings for us will be pretty minimal - it may progress the rat exercise science field though, so that's nice.

Snow Leopard · May 6, 2020

Andy said: ↑

Paper not currently available via Sci hub.

Chances are their chronic fatigue rat model is simply a rat exhausted via over exercise, so the value of the findings for us will be pretty minimal - it may progress the rat exercise science field though, so that's nice.
Click to expand...

Indeed, but it shows some relationship between thermoregulation, vascular regulation and exhaustion which may be interesting (if not applicable to ME or CFS).

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