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Griffith Uni: Shan et al - Decreased connectivity and increased BOLD complexity in the default mode network in individuals with CFS

Discussion in 'BioMedical ME/CFS Research' started by Andy, Nov 21, 2017.

  1. Andy

    Andy Committee Member (& Outreach when energy allows)

    Messages:
    14,314
    Location:
    Hampshire, UK
    Paywalled at http://online.liebertpub.com/doi/10.1089/brain.2017.0549
    Abstract only at https://www.ncbi.nlm.nih.gov/pubmed/29152994
     
    Webdog, Esther12, Nellie and 7 others like this.
  2. allyann

    allyann Established Member (Voting Rights)

    Messages:
    30
    Interesting conclusion:

    In conclusion, the DMN in CFS/ME is abnormal with more irregular activity, weaker connectivity, and more complex connectivity dynamics. In particular, the PCC activity in CFS/ME is more irregular and complex. Further, weaker connectivity among DMN hubs was observed and connection dynamics were more complex especially during the cognitive task. We argue that deficits in DMN could be energy expensive and may contribute to or cause the fatigue, cognitive symptoms and post exertional malaise of CFS.
     
    Webdog, Esther12, Nellie and 4 others like this.

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