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Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways, 2018, Howard et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Andy, Apr 17, 2018.

  1. Andy

    Andy Committee Member & Outreach

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    Note: the UK Biobank is not the same as the UK ME/CFS Biobank.
    Open access at https://www.nature.com/articles/s41467-018-03819-3
     
  2. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    There have been a lot of genetic false positives, but a high quality GWAS provides some confidence in the results. Certainly worth funding much research targeting these loci and seeing how they lead to depression.
     
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  3. Hutan

    Hutan Moderator Staff Member

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    The article that @Snowdrop posted here
    https://www.s4me.info/threads/all-mental-disorders-are-brain-disorders-not.3627/
    makes some comment about genetic studies in depression as well as some interesting comments about issues with other types of medical research into mental illnesses.

    I haven't read all of the Howard et al paper. But they seemed to find more correlated genes in broad depression, which seems to be a heterogeneous diagnosis, rather than MDD which seems more likely to be a discrete illness, suggesting that there should be a lower level of confidence that finding these genes will help understand underlying processes.
     
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