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Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways, 2018, Howard et al

Discussion in 'Other health news and research' started by Andy, Apr 17, 2018.

  1. Andy

    Andy Committee Member

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    Hampshire, UK
    Note: the UK Biobank is not the same as the UK ME/CFS Biobank.
    Open access at https://www.nature.com/articles/s41467-018-03819-3
     
  2. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    There have been a lot of genetic false positives, but a high quality GWAS provides some confidence in the results. Certainly worth funding much research targeting these loci and seeing how they lead to depression.
     
    Invisible Woman and Hutan like this.
  3. Hutan

    Hutan Moderator Staff Member

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    The article that @Snowdrop posted here
    https://www.s4me.info/threads/all-mental-disorders-are-brain-disorders-not.3627/
    makes some comment about genetic studies in depression as well as some interesting comments about issues with other types of medical research into mental illnesses.

    I haven't read all of the Howard et al paper. But they seemed to find more correlated genes in broad depression, which seems to be a heterogeneous diagnosis, rather than MDD which seems more likely to be a discrete illness, suggesting that there should be a lower level of confidence that finding these genes will help understand underlying processes.
     
    MEMarge, Snowdrop and Invisible Woman like this.

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