Genetics: Chromosome 15: CCPG1

I used the Open GWAS API to retrieve traits associated with the lead variants at each of the 8 DecodeME loci. I wrote more details on the CA10 locus thread.

Keep in mind that multiple traits being significant for the same variant doesn't necessarily mean the same variant is causal for all of the traits, since a variant can be significant just because it is correlated to (in LD with) another variant which is actually causal.

There was only one trait associated with rs7165327/15:54866724:A:G (the lead DecodeME variant near CCPG1), with p<1e-6 (rough Bonferroni correction for the ~50,000 traits in the database):
idtraitchrposition (GRCh37)rsideaneaeafbetasepn
eqtl-a-ENSG00000260916ENSG00000260916 (CCPG1)1555158922rs7165327GA0.323946-0.06478170.01270633.42168e-0731564
The G allele is associated with increased risk of ME/CFS and decreased expression of CCPG1. Note that CCPG1 was not a tier 1 gene in DecodeME, meaning the researchers did not find strong evidence for a shared causal variant that influences both ME/CFS risk and CCPG1 expression.
 
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