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Protocol Genetic and Metabolic Markers of BH4 Deficiency in Long COVID - OMF

Discussion in 'Long Covid research' started by Sly Saint, Aug 22, 2023.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

    The study expands on a previously-awarded proposal to thoroughly explore the underlying pathophysiology of post exertional malaise (PEM), the hallmark symptom of ME/CFS.


    • Laurel Crosby, PhD
    • Ronald W. Davis, PhD
    MEMarge, Kitty, Ash and 3 others like this.
  2. Amw66

    Amw66 Senior Member (Voting Rights)

    From memory BH4 synthesis is folate dependent , so SNPs on MTHFR can affect the amount of BH4 ( also impacts methionine and SAMe)

    Not so simple.
    MEMarge, alktipping, Kitty and 2 others like this.
  3. LarsSG

    LarsSG Senior Member (Voting Rights)

    Simarron recently found high serum BH4, so I wonder what the story is here. Are they talking about deficiency in some way that includes high serum levels?
    Jaybee00, MEMarge, Ash and 1 other person like this.
  4. Amw66

    Amw66 Senior Member (Voting Rights)

    Does this mean it's not doing what it's meant to be doing and thus is in serum when it shouldn't be ( a bit like functional B12 deficiency)?

    Could it be protective as something else is out of whack?

    When something so interdependent to many processes seems different would it not make sense to gather as much info on these other molecules concurrently?
    MEMarge likes this.

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