FOX0 pathway

Hi @wastwater. I admit I am bemused.

I looked at the diagram you link. It seems to be a complicated network diagram linking lots of biochemical pathways, one of which is labelled FOXO signalling pathway, drawn in the context of a lot of other pathways in a diagram labelled 'cell growth and death and cancer related signal transduction'.

The paper it is from is
''Analyzing the disease module associated with osteosarcoma via a network‑ and pathway‑based approach''

So it doesn't seem to be showing what the FOXO pathway is, but showing it's connection to other pathways in a particular cancer related context.

Did you have a particular reason why this is of interest?

 
Hi,I’m thinking I may have reduced FOX01 expression following my rare genetic conditions pathways

I was surprised to find FOX01 effects the thyroid as I hadn’t seen it before and wondered if this is the reason for my hypothyroidism

I only wanted to post the links diagram as the rest is a rare condition and probably confuses things

Then I saw Foxo mentioned in rheumatology and many other conditions
 
Merged

Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion​


www.nature.com

Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming - Cell Death & Disease

Macrophages are plastic cells that can switch among different states according to bioenergetic or biosynthetic requirements. Our previous work demonstrated that the transcription factor Forkhead Box Protein 1 (FoxO1) plays a pivotal role in regulating the function of macrophages, but the...
www.nature.com www.nature.com

I suspect genetically I may produce defective B cells and wondered what effect this may have
 
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