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fMRI cerebrovascular responses in CFS, Preliminary findings, 2019, Lara Mejia, VanElzakker et al. (Poster presentation)

Discussion in 'BioMedical ME/CFS Research' started by strategist, Oct 4, 2019.

  1. strategist

    strategist Senior Member (Voting Rights)

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    Last edited by a moderator: Oct 4, 2019
  2. strategist

    strategist Senior Member (Voting Rights)

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    For your convenience EF_SV4nXoAEmNYL.jpg
     
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  3. Trish

    Trish Moderator Staff Member

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    The poster is hard to read on Twitter. Here are a few key points:

    6 people with CFS did a before and during breath holding challenge with fMRI.

    Blood oxygenation level dependent (BOLD) images of the brain and were correlated with ongoing peripheral physiological changes to map the impairment of cerebrovascular reactivity (CRV) at rest and during a breath hold challenge.

    Findings showed that some had reduced CRV during resting state, and this was further reduced during breath holding.

    The preliminary conclusion from this is that there is abnormal CRV in some people with CFS.

    https://pbs.twimg.com/media/EF_SV4nXoAEmNYL?format=jpg&name=4096x4096

    Edit: Crossposted with Strategist!
     
  4. strategist

    strategist Senior Member (Voting Rights)

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    This seems broadly consistent the reportedly impaired systemic oxygen extraction, as well as with the propensity for ME/CFs patients to develop POTS (an illness of abnormal blood vessel regulation), the CPET abnormalities, and metabolic abnormalities.

    It's all still unclear but at least we have some findings that seem to be broadly coherent with each other.
     
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  5. beverlyhills

    beverlyhills Established Member (Voting Rights)

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    Keep in mind, anyone that has an illness that restricts mobility is going to have harder arteries.

    At least one of the researchers knows that and would say the velocity is different, or the percentage change, then it kind of deteriorates into a semantical argument, which academics love and I would lose.

    In order to correct for this you could co-administer a nitric oxide agonist.

    It is hard to really comment further given this just an abstract.
     
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