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Exercise modifies glutamate and other metabolic biomarkers in cerebrospinal fluid from Gulf War Illness and [ME/CFS], Baranuik et al, 2021

Discussion in 'ME/CFS research' started by Andy, Jan 14, 2021.

  1. Andy

    Andy Committee Member

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    18,103
    Location:
    Hampshire, UK
    Open access, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244116
     
    Hutan, Mij, Lidia and 7 others like this.
  2. strategist

    strategist Senior Member (Voting Rights)

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    4,545
    Carnitine is the only thing that seems to increase my ability to function somewhat.
     
    Lidia, Dolphin, ukxmrv and 2 others like this.
  3. Creekside

    Creekside Senior Member (Voting Rights)

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    459
    At one point in my ME (maybe year 12?) I developed worse symptoms after eating fatty meals. That was treated by taking carnitine with the meal. After a year or two of supplementing carnitine, the problem went away.
     
    mat likes this.
  4. mat

    mat Senior Member (Voting Rights)

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    135
    Maybe I should try L-Carnitine again. Have you noticed any difference during PEM? @strategist @Creekside
     
  5. Dolphin

    Dolphin Senior Member (Voting Rights)

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    3,621
    Just to point out that there has been a trial of L-carnitine for CFS.

    https://pubmed.ncbi.nlm.nih.gov/9018019/
    Though the abstract doesn't mention it, it used a dosage of 3000 mg/day.
    This is a larger dose than is usually recommended on product packaging.
     
    Last edited: Jan 15, 2021
    Michelle and mat like this.
  6. Creekside

    Creekside Senior Member (Voting Rights)

    Messages:
    459
    I didn't notice any difference during PEM. For me it was just 'fatty meal without carnitine = worse symptoms. With carnitine = no extra symptom severity'. I didn't need 3000 mg either; I think I took half a level tsp or so.
     
    Peter Trewhitt and mat like this.
  7. Dolphin

    Dolphin Senior Member (Voting Rights)

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    3,621
    Note that acetyl l-carnitine and l-carnitine are not necessarily the same. I have read before that acetyl l-carnitine acts more on the brain. This study would seem to bear this out. I read somewhere that propionylcarnitine is more similar to l-carnitine than acetyl l-carnitine.


    *In case this is not clear, this means 2 weeks after stopping treatment
     
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