Discussion in 'ME/CFS research' started by Andy, Jan 14, 2021.
Open access, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244116
Carnitine is the only thing that seems to increase my ability to function somewhat.
At one point in my ME (maybe year 12?) I developed worse symptoms after eating fatty meals. That was treated by taking carnitine with the meal. After a year or two of supplementing carnitine, the problem went away.
Maybe I should try L-Carnitine again. Have you noticed any difference during PEM? @strategist @Creekside
Just to point out that there has been a trial of L-carnitine for CFS.
Though the abstract doesn't mention it, it used a dosage of 3000 mg/day.
This is a larger dose than is usually recommended on product packaging.
I didn't notice any difference during PEM. For me it was just 'fatty meal without carnitine = worse symptoms. With carnitine = no extra symptom severity'. I didn't need 3000 mg either; I think I took half a level tsp or so.
Note that acetyl l-carnitine and l-carnitine are not necessarily the same. I have read before that acetyl l-carnitine acts more on the brain. This study would seem to bear this out. I read somewhere that propionylcarnitine is more similar to l-carnitine than acetyl l-carnitine.
*In case this is not clear, this means 2 weeks after stopping treatment
Separate names with a comma.