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Exercise Intolerance in Preload Failure Treated with Pyridostigmine (2018) Faria Urbina et al (mentions ME/CFS & POTS)

Discussion in 'Health News and Research unrelated to ME/CFS' started by Dolphin, May 8, 2018.

  1. Dolphin

    Dolphin Senior Member (Voting Rights)

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    rvallee, MEMarge, Hutan and 16 others like this.
  2. Seven

    Seven Senior Member (Voting Rights)

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    FYI, NAtural alternative? Huperzine A. Have not done much research but might try this.
     
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  3. NelliePledge

    NelliePledge Senior Member (Voting Rights)

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    are they saying there are people with ME who have this Preload Failure alongside ME or is it part of ME
     
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  4. JaimeS

    JaimeS Senior Member (Voting Rights)

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    I've tried Huperazine A for this reason -- no effect noted. Did it only for awhile and could really have had the wrong dosage, so YMMV.
     
  5. Ravn

    Ravn Senior Member (Voting Rights)

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    So did I. Three times with different doses. Each time I got a 'buzz' for a couple of days then crashed, stopped taking it and recovered to base line. Never had the courage to keep taking it through the crashes.
     
  6. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    The results provided in the abstract aren't the ones of interests - it is not peak cardiac output or VO2Peak that we are interested in, because it's possible that patients simply worked harder on the second test and achieved a higher heart rate. We're interested in stroke volume and O2 pulse. The lack of difference in ca-VO2Max leads to some doubt...

    The rationale behind Pyridostigmine is the assumption that there is something limiting cholinergic activity of specific nerves which is hypothesised to be the cause of the preload failure.

    The strange part to me is well, post-exercise hypotension is associated with increased parasympathetic activity in healthy normotensive people, so increasing cholinergic activity won't necessarily help in this case.
     
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  7. JaimeS

    JaimeS Senior Member (Voting Rights)

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    I feel like a little increased inflammation belongs in the "it may get worse before it can get better" category, because I feel better long-term from a little immune stimulation... but anything that makes you crash isn't a wait-and-see. :thumbsdown: You did the right thing.
     
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