Exercise-induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects, 2017, Baraniuk

Chronic fatigue syndrome: Changes in brain chemistry found

https://www.medicalnewstoday.com/articles/320051.php

Doing a search for "Chronic Fatigue Syndrome" on the above website https://www.medicalnewstoday.com/ returns 100 results. It may be of interest, but I'm not up to the task of deciding if it is.

If you put
site:medicalnewstoday.com intitle:Chronic+Fatigue+Syndrome
It will return results with Chronic Fatigue Syndrome in the Page Title. Should narrow things down. :)

It works for any site, just change the bit after "site:" to the site to search

Edited to add: That is for searching in a search engine, not an internal site search.
 
“A chronic and multisymptomatic disorder affecting returning military veterans and civilian workers of the 1990–91 Gulf war.”

“The United States Congress mandated the National Academies of Science Institute of Medicine to provide nine reports on Gulf War Syndrome since 1998.[17] Aside from the many physical and psychological issues involving any war zone deployment, Gulf War veterans were exposed to a unique mix of hazards not previously experienced during wartime. These included pyridostigmine bromide pills (given to protect troops from the effects of nerve agents), depleted uranium munitions, and anthrax and botulinum vaccines. The oil and smoke that spewed for months from hundreds of burning oil wells presented another exposure hazard not previously encountered in a war zone. Military personnel also had to cope with swarms of insects, requiring the widespread use of pesticides. High-powered microwaves were used to disrupt Iraqi communications, and though it is unknown whether this might have contributed to the syndrome, recent research suggests that safety limits for electromagnetic radiation are too lenient.[18]


https://en.m.wikipedia.org/wiki/Gulf_War_syndrome

I once had a friend whose brother returned home very ill from the Gulf War. At the time, he was not helped by the VA (Veterans Administratiin), because back then there was no such thing as “Gulf War Illness”. He was told he was a homosexual, his illness was related to being a homosexual, and his symptoms were not related to his service in the Gulf War. Fortunately he was married to a woman who was born in Germany, so they both left the US to reside in Germany, so he could seek medical help. To make a long story short, once in Germany he was properly medically treated and thus became well again.

So I find it sort of amusing that many years later we have a term called “Gulf War Illness”, and now it’s being studied with ME (to look for similarities?). But looking at the list of chemicals/toxins the soldiers were exposed to, along with microwaves, it’s no surprise some returned very ill. And if my memory serves me correctly, the soldiers were issued chemical hazard suits, but because they were stationed in the desert, it was impractical to wear them. And as I recall the chemical alarm warnings were frequently going off, and after awhile the soldiers ignored the alarms (and thus did not put on their suits).

Note: Don’t mean to offend anyone, but in 1990/1991 some people in the US were cruel and dismissive toward others deemed as not being heterosexual.
 
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ME Association review of this paper
Conclusion
This study is yet another to add to the many great pieces of biomedical research to have emerged this year, further supporting what we already know; chronic fatigue syndrome is very real and not ‘in the mind’ but – in the brain.

Significant pathophysiological differences were demonstrated between CFS and GWI, distinguishing them as two separate conditions. The paper concluded:
‘Despite the symptom overlap of CFS, GWI and other illnesses in the differential diagnosis, the distinct exercise-induced miRNA patterns in cerebrospinal fluid imply separate mechanisms for post-exertional malaise in these diseases.’

Although these results do not point towards a diagnostic marker or treatment yet, it certainly adds to the knowledge of potential brain inflammation and demonstrates the very real effects of PEM. As the field of miRNA research expands, so will our knowledge of what these results mean for people with ME/CFS.
PDF download - http://www.meassociation.org.uk/wp-...chemistry’-after-exercise-in-CFS-06.12.17.pdf
 
No, the brain is physical. If someone cleaves your brain apart with an axe ... it ain't psychological.

Well, sure. I appreciate Cartesian Dualism as much as the next person, and I trust on paper so does the BPS crowd. Regardless, it is what they might do with the dichotomy between brain and mind that is troublesome.

I don't find it a stretch to imagine they could use some of these abnormal brain findings to build upon the platform that what we experience, we experience, but it is not based on any pathogen or immune response, and so can be overcome with corrective behavioral changes and better thinking, and maybe a dollop of psychogenics.

This effortlessly persistent comparison default by some to depression or bipolar disorder is concerning, especially when brain cancer or Parkinson's or MS are just as relevant without the dangerous references.
 
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He also did a study after 9/11 to show that ill effects were psychological, not the result of toxins. It said so on a TV documentary I think. He was chief psychologist or something like that for NATO. The way ME has been treated is very like the ways the CIA are documented to use to discredit ideas. I have always suspected that knighthood.
 
Thanks @Valentijn and @Mithriel.

The knighthood is political, my opinion.

It's not that I view it as unlikely that he may have worked for the Pentagon, too, it's that I like substance. Your replies give me an idea.

@duncan, how can you link the ME/GWI study to psycho statements? I don't see your point clearly, although I have a feeling of your meaning.
 
how can you link the ME/GWI study to psycho statements? I don't see your point clearly, although I have a feeling of your meaning.

History.

Not so much with miRNA yet, but look what they did with IL-6. It's not BPS for nothing; it seems to me that elements within that school have demonstrated a willingness to take any biological component and fold it to suit their psych purposes.

I wonder, why give them a ready made springboard like depression - which most of us I would imagine feel is biological in origin - and who knows where they might run with it?

So...don't give them that springboard.
 
Well, sure. I appreciate Cartesian Dualism as much as the next person, and I trust on paper so does the BPS crowd. Regardless, it is what they might do with the dichotomy between brain and mind that is troublesome.

I don't find it a stretch to imagine they could use some of these abnormal brain findings to build upon the platform that what we experience, we experience, but it is not based on any pathogen or immune response, and so can be overcome with corrective behavioral changes and better thinking, and maybe a dollop of psychogenics.

This effortlessly persistent comparison default by some to depression or bipolar disorder is concerning, especially when brain cancer or Parkinson's or MS are just as relevant without the dangerous references.
I'm a software engineer, and my perception of brain and mind is much more prosaic than Cartesian Dualism, which to me feels too ethereal/spiritual. As a very loose modelling, I think of the brain roughly akin to the various microprocessor and programmable logic chips that form part of a computer, and the mind roughly akin to the software and firmware that runs on those chips. The physical brain hosting the software and programmable logic that 'runs' within it; nothing whimsical running without. Needless to say it's just a working analogy that works for me, nothing more.

But I do take your point, that there are those who will read 'brain' and claim 'mind'. But hopefully there will be enough others who will see how daft that would be.
 
Are you saying we shouldn't study bio-medical aspects of the brain because results might be twisted by the BPS crowd?

No. I'm saying drawing some correlations invite problems which by now we should be familiar with - and about which we should know better.
 
What happened with IL-6? Did the BPS people invent a fairytale about how the psyche or an underlying conflict influences IL-6?


@Inara, over the years there have been a number of reports linking oscillating levels of Interleukin 6 with ME/CFS. I think a theory was early on IL-6 was low, but as the disease progressed values climbed. The hope was perhaps we had a workable biomarker.

However, as I recall, a psych contingent countered by saying IL-6 demonstrated irregular levels in both depression and anxiety, so ME/CFS by extension likely fell on the spectrum of "stress-related" disorders.

My point was we have already seen how they could manipulate cytokine imbalances to fit their narrative. Perhaps it would be prudent to anticipate something similar here, especially when we potentially provide fodder for their argument. Our's is a community replete with cautionary tales - I am simply recommending learning from them.
 
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