Evidence for a genetic component in ME/CFS - discussion thread

Simon M said:
there is a review paper in press that looks at these issues and might be available quite soon.
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Oh wow thanks. Congrats with the paper!

Relevant section from the paper:
Evidence that CFS risk is inherited

Various observations are consistent with genetic factors contributing to CFS risk for some individuals. Individuals with a CFS diagnosis (Fukuda or ICD-9 code 780.71 criteria) have a significant excess relatedness over the wider population for both close (first or second degree) and distant (third degree) relatives (16, 22). Of three studies that have estimated narrow-sense heritability (h 2 ) using large cohorts, two reported non-zero h 2 -values that provide evidence for heritability of risk for CFS and, presumably, ME/CFS. An analysis of USA health insurance claimed a high narrow-sense heritability ( ) of CFS (23) whereas an analysis of UK Biobank individuals self-reporting a CFS diagnosis reported a less striking heritability (single nucleotide polymorphism- [SNP-] based approximate h 2 = 0.08 with low confidence) (24, http://www.nealelab.is/uk-biobank). The third, a large twin-based study of CFS-like cases, produced an inconclusive result, with the 95% confidence interval of h 2 including zero [0.03 (0.00–0.65)] (25).
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