I thought I'd be the first to take advantage of this new MEpedia sub-fourm, by posting a link to a new MEpedia article I just completed today, which is found here: Non-cytolytic enterovirus — MEpedia article This MEpedia article is a (hopefully) accessible introduction to non-cytolytic enterovirus, the aberrant and mutated form of enterovirus found as a persistent infection in the tissues of many ME/CFS patients. Chronic non-cytolytic enterovirus infection is an important subject, because many doctors even today are taught that enteroviruses do not form chronic infections, and thus the concept of an enteroviral infection that persists in the muscle, digestive tract and brain tissues of ME/CFS patients does not quite fit their training (even though numerous studies have demonstrated this to be the case). Through the work of Professor Nora Chapman and her colleagues, we now understand the mechanism of enteroviral persistence in the tissues: in brief, her research demonstrates that that certain mutations which enterovirus acquires in the host during the acute stage of infection can transform it into a pathogen with a radically altered lifecycle, and a pathogen that can form persistent infections in the host tissues. Prof Chapman's identification of the mechanism behind non-cytolytic enterovirus has import not just for ME/CFS, but also for several other diseases in which persistent enterovirus infections of the tissues are found, including chronic myocarditis, dilated cardiomyopathy (the reason for around 45% of all heart transplants), type 1 diabetes, motor neuron disease, Sjogren's syndrome and Parkinson's disease. The working hypothesis is that the aberrant non-cytolytic form of enterovirus may be a cause for all these illnesses. Thus the medical significance of non-cytolytic enterovirus goes beyond just ME/CFS. Anyway, if you get a chance to have a look at this article, I'd be pleased to hear any feedback or suggestions. Was it reasonably easy to grasp, or were there certain concepts or certain areas that were hard to follow in the article? The aim is to make the subject accessible to a lay audience. I tried to write the article so that the easiest to understand sections are first, and the more difficult material appears later. So reading say the first four sections should be relatively easy, and give an overview and basic understanding. Then if you want to delve deeper, the subsequent sections will take you in further. But the first 4 sections may provide an adequate overview for most people. I wanted to try to write an accessible article on non-cytolytic enterovirus for a long time, so I am thankful to @JenB for the encouragement to do some editing on the enterovirus pages of MEpedia, which spurred this article into existence.