Evaluation of four clinical laboratory parameters for the diagnosis of myalgic encephalomyelitis (2018) De Meirleir et al

https://www.ncbi.nlm.nih.gov/pubmed/30463572
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1696-z

 

Anybody had time to look at this yet?

 

I hope they will test more people and people with other diseases. I think a biomarker eventually will be different tests taken together to form a diagnosis, so this seems like a good start. We will just have to see if these parameters are really specific for ME.

I had all these levels tested and in my case it's correct.

 

My test results (sCD14, PGE and Interleukin 8) were abnormal too.

 

I have been expecting a finding of elevated PGE2 for two and a half decades. Why does it take so long? (rhetorical question)

It seemed to me, based on early work by Dr Andriya Martinovic, plus work by Martin L Pall and others, that this was a fully expected consequence. I was trying various treatments based on this idea through most of the 90s.

By itself PGE2 shows potential pathophysiology, its not diagnostic. I don't want to say anything about the other three substances yet. We will have to see how further research progresses before we know if this is diagnostically useful.