As it seems a lot of people go on to develop ME following a virus (children in partic seem particularly susceptible after mono,EBV), I thought I'd take a look at the NICE guidelines for EBV. " Management How should I manage a person with suspected or confirmed glandular fever? Give information and advice: Advise on the use of paracetamol or ibuprofen to relieve pain and fever symptoms. See the CKS topics on Analgesia - mild-to-moderate pain and NSAIDs - prescribing issues for more information. Explain the expected course of the illness and reassure the person that symptoms usually last for 2–3 weeks. Tiredness is common and is often the last symptom to resolve. Advise the person: That exclusion from work or school is not necessary. To return to normal activities as soon as possible. If they are tired, they should tailor their activities to what they can manage comfortably. Bed rest is not normally needed. To limit spread of the disease, by avoiding kissing and sharing eating or drinking utensils, and to thoroughly clean all items that may have been contaminated by saliva. To avoid contact or collision sports or heavy lifting for the first month of the illness (to reduce the risk of splenic rupture). Advise the person to seek urgent medical advice if they: Develop stridor or respiratory difficulty. Have difficulty swallowing fluids or have signs of dehydration, such as reduced urine output. Become systemically very unwell. Develop abdominal pain (may indicate splenic rupture). If a person has ongoing fatigue, see the section on Assessment in the CKS topic on Tiredness/fatigue in adults for more information on ongoing management." full text here: https://cks.nice.org.uk/glandular-fever-infectious-mononucleosis#!scenario I was rather surprised to find that the evidence this is based on is very sparse and that rest is not really deemed necessary, in fact they say that normal activity should be resumed as soon as possible. I have not had mono/EBV myself so cannot comment from personal experience, but from an ME perspective (and having had some kind of virus followed by pneumonia before onset) this seems very counter intuitive. (NB: I haven't read the research) eta: webmd has different advice: " Get plenty of rest. Drink a lot of water and other liquids to stay hydrated. Suck on lozenges or ice pops, or gargle with warm salt water, to make your sore throat feel better. Take painkillers like acetaminophen or ibuprofen to bring down fever and relieve body aches. (Don't give aspirin to children under 19 years of age because of the risk of a rare but serious condition called Reye’s syndrome.) Ease back into work or school, taking things slowly until you feel better. For a month or so, avoid sports, heavy lifting, or other vigorous activities in which you could injure your spleen." https://www.webmd.com/a-to-z-guides/epstein-barr-virus#2 And the NHS.......... " You should: rest and sleep drink plenty of fluids (to avoid dehydration) take painkillers like paracetamol or ibuprofen (don't give aspirin to children under 16) don't drink alcohol - your liver might be weak while you have glandular fever" "You should feel better within 2 to 3 weeks. Some people might feel extremely tired for months." " Glandular fever complications Most people get better with no problems. Sometimes glandular fever may lead to other illnesses, such as: lower level of blood cells, such as anaemia an infection, such as pneumonia a neurological illness, such as Guillain-Barre syndrome or Bell's palsy Page last reviewed: 17/11/2017"