Jonathan Edwards
Senior Member (Voting Rights)
Audrey Ryback sent me this rather interesting paper, which analyses the different genetics of another disease with two age peaks, vitiligo.
www.nature.com

Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression - Nature Communications
GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.
