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Early menopause and other gynecologic risk indicators for CFS in women, 2015, Boneva, Lin, Unger

Discussion in 'BioMedical ME/CFS Research' started by Arnie Pye, Feb 19, 2018.

  1. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

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    Thought this might be of interest to some people :

    Title : Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women

    Link to whole paper : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745581/

    Abstract
    Objective
    This study aims to examine whether gynecologic conditions are associated with chronic fatigue syndrome (CFS).

    Methods
    This study includes a subset of 157 women from a population-based case-control study in Georgia, United States, conducted in 2004-2009. Gynecologic history was collected using a self-administered questionnaire. Crude odds ratios (ORs) with 95% CIs and ORs adjusted for body mass index and other covariates, where relevant, were estimated for gynecologic conditions between 84 CFS cases and 73 healthy controls.

    Results
    Cases and controls were of similar age. Women with CFS reported significantly more gynecologic conditions and surgical operations than controls: menopause status (61.9% vs 37.0%; OR, 2.37; 95% CI, 1.21-4.66), earlier mean age at menopause onset (37.6 vs 48.6 y; adjusted OR, 1.22; 95% CI, 1.09-1.36), excessive menstrual bleeding (73.8% vs 42.5%; adjusted OR, 3.33; 95% CI, 1.66-6.70), bleeding between periods (48.8% vs 23.3%; adjusted OR, 3.31; 95% CI, 1.60-6.86), endometriosis (29.8% vs 12.3%; adjusted OR, 3.67; 95% CI, 1.53-8.84), use of noncontraceptive hormonal preparations (57.1% vs 26.0%; adjusted OR, 2.95; 95% CI, 1.36-6.38), nonmenstrual pelvic pain (26.2% vs 2.7%; adjusted OR, 11.98; 95% CI, 2.57-55.81), and gynecologic surgical operation (65.5% vs 31.5%; adjusted OR, 3.33; 95% CI, 1.66-6.67), especially hysterectomy (54.8% vs 19.2%; adjusted OR, 3.23; 95% CI, 1.46-7.17). Hysterectomy and oophorectomy occurred at a significantly younger mean age in the CFS group than in controls and occurred before CFS onset in 71% of women with records of date of surgical operation and date of CFS onset.

    Conclusions
    Menstrual abnormalities, endometriosis, pelvic pain, hysterectomy, and early/surgical menopause are all associated with CFS. Clinicians should be aware of the association between common gynecologic problems and CFS in women. Further work is warranted to determine whether these conditions contribute to the development and/or perpetuation of CFS in some women.
     
    Hutan, ahimsa, MEMarge and 6 others like this.
  2. Dolphin

    Dolphin Senior Member (Voting Rights)

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    Uses the Reeves et al. 2005 criteria which are generally accepted to be terrible. Found a prevalence for CFS of 2.54% in Georgia.
     
    Arnie Pye, MEMarge, Hutan and 2 others like this.
  3. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

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    I'm not familiar with the various criteria used. I'm still a newbie when it comes to the nitty-gritty, and my memory isn't up to much these days. Do you have a link?
     
  4. Dolphin

    Dolphin Senior Member (Voting Rights)

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    2 critiques:

    Jason LA, Najar N, Porter N, Reh C. Evaluating the Centers for Disease Control's empirical chronic fatigue syndrome case definition. Journal of Disability Policy Studies 2009;20;93.
    http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.508.1082&rep=rep1&type=pdf

    Jason LA, & Richman JA. How science can stigmatize: The case of chronic fatigue syndrome. Journal of CFS 2007;14:85-103.
    https://sci-hub.tw/http://www.tandfonline.com/doi/abs/10.3109/10573320802092146
     
  5. Arnie Pye

    Arnie Pye Senior Member (Voting Rights)

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  6. TigerLilea

    TigerLilea Senior Member (Voting Rights)

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    I've heard this before, also. However, I didn't have any of the problems that they list. I went through meno at 52 which is the average age.
     
    MEMarge, Hutan and Invisible Woman like this.

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