Early diagnostics of autoinflammatory disorders associated with post-viral CFS and cognitive impairments in chronic ... herpes, 2021, Nesterova et al

Samuel

Samuel

Senior Member (Voting Rights)
vvv
Source: Medical Immunology
Vol 23, #4, pp 975-980
Date: July/August 2021
URL: https://www.mimmun.ru/mimmun/article/view/2439
https://www.mimmun.ru/mimmun/article/view/2439/1456


Early diagnostics of autoinflammatory disorders associated
with post-viral chronic fatigue syndrome and cognitive
impairments in chronic mixed herpes viral infections
----------------------------------------------------------
Nesterova I.V(a), Khalturina E.O(b,*)
a Peoples' Friendship University of Russia, Moscow, Russian
Federation
b I. Sechenov First Moscow State Medical University (Sechenov
University), Moscow, Russian Federation
* Corresponding author: Khalturina Eugenia O.I. Sechenov First
Moscow State Medical University 117452, Russian Federation,
Moscow, Mochovaya, 11, bild.10. Phone: 7 (916) 650-15-14.
E-mail: jane_k@inbox.ru

Received 22.03.2021
Revision received 02.06.2021
Accepted 15.06.2021


Abstract

The steady increase in the number of autoimmune diseases and immune-mediated auto inflammatory processes causes an increased interest of doctors of all specialties in this topic and makes the issue of early detection of autoimmune disorders/autoimmune syndrome (AS) extremely urgent. These disorders often develop against the backdrop of an atypical stream of chronic active viral infections caused by persistent viruses, in particular those of the Herpesviridae family, and remain undiagnosed due to polysymptomatic disease, and various 'clinical masks' of the disorders caused by them. The semi-quantitative method developed by us for screening assessment of the content of autoantibodies in the blood serum of patients suffering from ACAI caused by herpes viruses using the ELISA method (Immunodot) is a highly specific screening method that can allow for an objective assessment of the dynamics of the autoimmune process, as well as control the effectiveness of the ongoing complex antiviral and immunomodulatory therapy. The detection of autoantibodies of various specificity in the blood serum of patients suffering from an atypical chronic active infection caused by herpes viruses (ACAI) is an early diagnostic marker, necessary, first of all, to identify autoimmune pathology of the nervous system, which is associated with a long course of the active mixed herpes-viral process.

Keywords: herpesviruses, autoantibodies, gangliosides, autoimmunity, immune dysfunction, post-viral chronic fatigue syndrom
^^^

from m-a fluks, public
 
Samuel said:
vvv
Source: Medical Immunology
Vol 23, #4, pp 975-980
Date: July/August 2021
URL: https://www.mimmun.ru/mimmun/article/view/2439
https://www.mimmun.ru/mimmun/article/view/2439/1456


Early diagnostics of autoinflammatory disorders associated
with post-viral chronic fatigue syndrome and cognitive
impairments in chronic mixed herpes viral infections
----------------------------------------------------------
Nesterova I.V(a), Khalturina E.O(b,*)
a Peoples' Friendship University of Russia, Moscow, Russian
Federation
b I. Sechenov First Moscow State Medical University (Sechenov
University), Moscow, Russian Federation
* Corresponding author: Khalturina Eugenia O.I. Sechenov First
Moscow State Medical University 117452, Russian Federation,
Moscow, Mochovaya, 11, bild.10. Phone: 7 (916) 650-15-14.
E-mail: jane_k@inbox.ru

Received 22.03.2021
Revision received 02.06.2021
Accepted 15.06.2021


Abstract

The steady increase in the number of autoimmune diseases and immune-mediated auto inflammatory processes causes an increased interest of doctors of all specialties in this topic and makes the issue of early detection of autoimmune disorders/autoimmune syndrome (AS) extremely urgent. These disorders often develop against the backdrop of an atypical stream of chronic active viral infections caused by persistent viruses, in particular those of the Herpesviridae family, and remain undiagnosed due to polysymptomatic disease, and various 'clinical masks' of the disorders caused by them. The semi-quantitative method developed by us for screening assessment of the content of autoantibodies in the blood serum of patients suffering from ACAI caused by herpes viruses using the ELISA method (Immunodot) is a highly specific screening method that can allow for an objective assessment of the dynamics of the autoimmune process, as well as control the effectiveness of the ongoing complex antiviral and immunomodulatory therapy. The detection of autoantibodies of various specificity in the blood serum of patients suffering from an atypical chronic active infection caused by herpes viruses (ACAI) is an early diagnostic marker, necessary, first of all, to identify autoimmune pathology of the nervous system, which is associated with a long course of the active mixed herpes-viral process.

Keywords: herpesviruses, autoantibodies, gangliosides, autoimmunity, immune dysfunction, post-viral chronic fatigue syndrom
^^^

from m-a fluks, public
Click to expand...

A study still in progress?
 
There is an English version. click on the first link and look for ENG(PDF)

It's one of those ones where you wonder if there is a kernel of something important hidden by the very poor presentation and missing information.
 
They had 20 controls and 20 patients. The patients were highly highly selected, in particular having many infections including recurrent herpes outbreaks:
There were followed up 548 subjects, of both sexes, aged 25 to 68 years, suffering from atypical chronic active mono- and mixed HVI. Among them were selected 20 patients with mixed HVI suffering from severe disorders of the mnestic sphere, post- viral syndrome of chronic fatigue and immune dysfunction, clinical signs of developing autoimmune syndrome – fibromyalgia, cephalgia, neuropathic pain and paresthesia, etc. comprising a study group.

The inclusion criteria were: clinical signs of the immunocompromised state characteristic of ACA HVI. Criteria for immunocompromised state are presented by repeated acute respiratory viral infections of bacterial-viral etiology with incidence rate up to 10-12 times a year, chronic recurrent herpes-viral infections (HSV1, HSV2), chronic CMV, EBV and ННV6 infections, chronic bacterial and fungal co-infections. The comparison group included 20 sex- and age-matched apparently healthy adults.
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It's a bit hard to know what they found in terms of autoantibodies. But they seemed to find a lot of autoantibodies to gangliosides. I don't think they tell us what they found in the controls.

Among them, autoantibodies to GM1 ganglioside are found in 80% of blood samples. Autoantibodies against the GM1 ganglioside initiate damage to the axolemma and also block voltage-gated calcium channels. It should be noted that often it is possible to identify a combination of various autoantibodies to gangliosides in the blood of patients with various clinical forms of the syndrome.
Click to expand...

It was shown that the largest amount of serum autoantibodies in examined patients was specific to a wide range of gangliosides. Among them, antibodies to GM1 ganglioside were determined – in 70%; GM3 – 43%; GD2.3-21.4%; sulfatides – 32%. Autoantibody levels varied in a wide range from low (30 U) to high (100 U) and correlated with the activity of the viral process and clinical symptoms.
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They give us a categorisation of the level of the autoantibodies (low, high, etc), but they don't actually report what levels were found.

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So, as much as I would like the answer to ME/CFS to be an autoantibody, I'm left skeptical and confused.
 
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This is the first paper I have seen with patient cohort criteria which match my own condition.

ACAI (atypical chronic active infection) caused by mixed HVIs (herpes virus infections) is exactly what I have (EBV + HSV2).

The medics I have seen in the UK do not acknowledge this condition exists.
 
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