1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 18th March 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Dr Jose Montoya, Live Webcast from Stanford, Jan 18th 7PM PST

Discussion in 'General ME/CFS news' started by MErmaid, Jan 7, 2018.

  1. Forbin

    Forbin Senior Member (Voting Rights)

    Messages:
    1,581
    Location:
    USA
    Among other things, Tofacitinib is used to treat Inflammatory Bowel Disease.

    One cause of IBD are changes in the intestinal microbiota.


    There have been a couple of papers showing altered composition of the gut microbiota in ME/CFS.

    There is a history of IBD in my family, so it's tempting for me to wonder if some chronic alteration of the gut microbiome, and the resulting immune response, could be the engine driving ME/CFS.
     
  2. Solstice

    Solstice Senior Member (Voting Rights)

    Messages:
    1,154
    I wonder if he knows about filgotinib then, by the looks of it a way more accurate jak-inhibitor. The gist I get from this theory is that changes in intestinal microbiota cause inflammation, which causes an exaggerated immune response, which keeps the intestinal microbiota screwy. A jak-inhibitor would take out the inflammation and the immune response would then perhaps be gone? Allowing things to get back to normal?
     
    MeSci, Helen, Forbin and 2 others like this.
  3. Diwi9

    Diwi9 Senior Member (Voting Rights)

    Messages:
    160

Share This Page