Distinct functional connectivity patterns in [ME/CFS & LC] during cognitive fatigue: a 7 Tesla task-fMRI study, 2026, Inderyas, Marshall-Gradisnik+

[Sean]

I mean it's pretty obvious looking at the daily discussions on S4ME over a decade that one thing ME/CFS patients absolutely do not lack is motivation (and interest and desire and...).

Indeed. It has been noted for decades, including in the formal literature IIRC, that one way to differentiate ME/CFS from depression is to ask a patient what they would do if they were suddenly cured.

ME/CFS patients typically have a long list of things they would like to do. Depressive patients just shrug their shoulders.

 

[Utsikt]

Indeed. It has been noted for decades, including in the formal literature IIRC, that one way to differentiate ME/CFS from depression is to ask a patient what they would do if they were suddenly cured.

ME/CFS patients typically have a long list of things they would like to do. Depressive patients just shrug their shoulders.

I’d answer «I have no idea because I don’t see any use in speculating in that when I’m so far away from it».

 

[rvallee]

Our findings of reduced dopaminergic hippocampal-nucleus-accumbens connectivity imply blunted motivation

If that's because the areas involved are typically described as involved in motivation, then that means that traditional description is wrong or incomplete, not that there is such a finding. If anything, I actually see elevated motivation, taking it to relentless levels. I have never experienced reduced motivation, I am actually fuming with it.